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10.3389/fimmu.2020.581758 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.581758 33162995!7580254!33162995     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 581758 Nephropedia Template TP {{tp|p=33162995|t=2020. X-Linked Immunodeficient Mice With No Functional Bruton s Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure |pdf=|usr=}}{{33162995}} gab.com Text X-Linked Immunodeficient Mice With No Functional Bruton s Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33162995 #FOAvip We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymicrobial sepsis and reduces hyperimmune stimulation ("cytokine storm") induced by an overwhelming bacterial infection. Protection is due in part to enhanced bacterial phagocytosis in vivo, changes in lipid metabolism and decreased activation of NF-kappaB and the NLRP3 inflammasome. The inactivation of BTK leads to reduced innate immune cell recruitment and a phenotypic switch from M1 to M2 macrophages, aiding in the resolution of sepsis. We have also found that BTK expression in humans is increased in the blood of septic non-survivors, while lower expression is associated with survival from sepsis. Importantly no further reduction in organ damage, cytokine production, or changes in plasma metabolites is seen in Xid mice treated with the BTK inhibitor ibrutinib, demonstrating that the protective effects of BTK inhibitors in polymicrobial sepsis are mediated solely by inhibition of BTK and not by off-target effects of this class of drugs. Twit Text FOAVip X-Linked Immunodeficient Mice With No Functional Bruton s Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33162995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33162995 #FOAvip English Wikipedia <ref>{{Cite pmid|33162995}}</ref> X-Linked Immunodeficient Mice With No Functional Bruton s Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure #MMPMID33162995 O'Riordan CE; Purvis GSD; Collotta D; Krieg N; Wissuwa B; Sheikh MH; Ferreira Alves G; Mohammad S; Callender LA; Coldewey SM; Collino M; Greaves DR; Thiemermann C Front Immunol 2020[]; 11 (ä): 581758 PMID33162995show ga We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymicrobial sepsis and reduces hyperimmune stimulation ("cytokine storm") induced by an overwhelming bacterial infection. Protection is due in part to enhanced bacterial phagocytosis in vivo, changes in lipid metabolism and decreased activation of NF-kappaB and the NLRP3 inflammasome. The inactivation of BTK leads to reduced innate immune cell recruitment and a phenotypic switch from M1 to M2 macrophages, aiding in the resolution of sepsis. We have also found that BTK expression in humans is increased in the blood of septic non-survivors, while lower expression is associated with survival from sepsis. Importantly no further reduction in organ damage, cytokine production, or changes in plasma metabolites is seen in Xid mice treated with the BTK inhibitor ibrutinib, demonstrating that the protective effects of BTK inhibitors in polymicrobial sepsis are mediated solely by inhibition of BTK and not by off-target effects of this class of drugs. |Adenine/analogs & derivatives/pharmacology[MESH] |Agammaglobulinaemia Tyrosine Kinase/*metabolism[MESH] |Animals[MESH] |Benzamides/pharmacology[MESH] |Disease Models, Animal[MESH] |Inflammasomes/metabolism[MESH] |Macrophages/drug effects/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred CBA[MESH] |Multiple Organ Failure/drug therapy/*metabolism[MESH] |Phagocytosis/drug effects[MESH] |Piperidines/pharmacology[MESH] |Protein Kinase Inhibitors/pharmacology[MESH] |Pyrazines/pharmacology[MESH] |Sepsis/drug therapy/*metabolism[MESH]X-Linked Immunodeficient Mice With No Functional Bruton s Tyrosine Kin(epmc).pdf DeepDyve Pubget Overpricing