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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Diabetes+Metab+Syndr 2020 ; 14 (6): 2103-2109 Nephropedia Template TP
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Charlson comorbidity index and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis #MMPMID33161221
Tuty Kuswardhani RA; Henrina J; Pranata R; Anthonius Lim M; Lawrensia S; Suastika K
Diabetes Metab Syndr 2020[Nov]; 14 (6): 2103-2109 PMID33161221show ga
BACKGROUND AND AIMS: The ongoing COVID-19 pandemic is disproportionately affecting patients with comorbidities. Therefore, thorough comorbidities assessment can help establish risk stratification of patients with COVID-19, upon hospital admission. Charlson Comorbidity Index (CCI) is a validated, simple, and readily applicable method of estimating the risk of death from comorbid disease and has been widely used as a predictor of long-term prognosis and survival. METHODS: We performed a systematic review and meta-analysis of CCI score and a composite of poor outcomes through several databases. RESULTS: Compared to a CCI score of 0, a CCI score of 1-2 and CCI score of >/=3 was prognostically associated with mortality and associated with a composite of poor outcomes. Per point increase of CCI score also increased mortality risk by 16%. Moreover, a higher mean CCI score also significantly associated with mortality and disease severity. CONCLUSION: CCI score should be utilized for risk stratifications of hospitalized COVID-19 patients.