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10.1016/j.ygeno.2020.11.003 http://scihub22266oqcxt.onion/10.1016/j.ygeno.2020.11.003 33161087!7644180!33161087     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genomics 2020 ; 112 (6): 5331-5342 Nephropedia Template TP {{tp|p=33161087|t=2020. Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus |pdf=|usr=}}{{33161087}} gab.com Text Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus JO: Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33161087 #FOAvip To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in GISAID till 21 August 2020. Globally, nsp1/nsp2 and orf7a/orf3a were the most mutation-ridden non-structural and structural genes respectively. Phylogeny of 4618 spatiotemporally-representative genomes revealed that entities belonging to the early lineages are mostly spread over Asian countries, including India, whereas the recently-derived lineages are more globally distributed. Of the total 20,163 instances of polymorphism detected across global genomes, 12,594 and 7569 involved transitions and transversions, predominated by cytidine-to-uridine and guanosine-to-uridine conversions, respectively. Positive selection of nonsynonymous mutations (dN/dS >1) in most of the structural, but not the non-structural, genes indicated that SARS-CoV-2 has already harmonized its replication/transcription machineries with the host metabolism, while it is still redefining virulence/transmissibility strategies at the molecular level. Mechanistic bases and evolutionary/pathogenicity-related implications are discussed for the predominant mutation-types. Twit Text FOAVip Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus ????Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33161087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33161087 #FOAvip English Wikipedia <ref>{{Cite pmid|33161087}}</ref> Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus #MMPMID33161087 Roy C; Mandal SM; Mondal SK; Mukherjee S; Mapder T; Ghosh W; Chakraborty R Genomics 2020[Nov]; 112 (6): 5331-5342 PMID33161087show ga To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in GISAID till 21 August 2020. Globally, nsp1/nsp2 and orf7a/orf3a were the most mutation-ridden non-structural and structural genes respectively. Phylogeny of 4618 spatiotemporally-representative genomes revealed that entities belonging to the early lineages are mostly spread over Asian countries, including India, whereas the recently-derived lineages are more globally distributed. Of the total 20,163 instances of polymorphism detected across global genomes, 12,594 and 7569 involved transitions and transversions, predominated by cytidine-to-uridine and guanosine-to-uridine conversions, respectively. Positive selection of nonsynonymous mutations (dN/dS >1) in most of the structural, but not the non-structural, genes indicated that SARS-CoV-2 has already harmonized its replication/transcription machineries with the host metabolism, while it is still redefining virulence/transmissibility strategies at the molecular level. Mechanistic bases and evolutionary/pathogenicity-related implications are discussed for the predominant mutation-types. |*Evolution, Molecular[MESH] |*Genome, Viral[MESH] |*Mutation Accumulation[MESH] |Asia[MESH] |Genomics/methods[MESH] |India[MESH] |Mutation Rate[MESH] |Mutation, Missense[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH] |Viral Proteins/genetics[MESH]Trends of mutation accumulation across global SARS-CoV-2 genomes: Impl(epmc).pdf DeepDyve Pubget Overpricing