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10.1016/j.cca.2020.10.035 http://scihub22266oqcxt.onion/10.1016/j.cca.2020.10.035 33159952!7642750!33159952     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chim+Acta 2020 ; 511 (ä): 352-359 Nephropedia Template TP {{tp|p=33159952|t=2020. Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases |pdf=|usr=}}{{33159952}} gab.com Text Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases JO: Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=33159952 #FOAvip BACKGROUND: Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays differ in the target antigen specificity, e.g. of antibodies directed against the viral spike or the nucleocapsid protein, and in the spectrum of detected immunoglobulins. The aim of the study was to evaluate the performance of two different routinely used immunoassays in hospitalized and outpatient COVID-19 cases. METHODS: The test characteristics of commercially available spike1 protein-based serological assays (Euroimmun, EI-assays), determining IgA or IgG and nucleocapsid-based assays (Virotech, VT-assays) determining IgA, IgM or IgG were compared in 139 controls and 116 hospitalized and outpatient COVID-19 cases. RESULTS: Hospitalized COVID-19 patients (n = 51; 115 samples) showed significantly higher concentrations of antibodies against SARS-CoV-2 and differed from outpatient cases (n = 65) by higher age, higher disease severity scores and earlier follow up blood sampling. Sensitivity of the two IgG assays was comparable in hospitalized patients tested >/= 14 days (EI-assay: 88%, CI(95%) 67.6-99.9; VT-assay: 96%, CI(95%) 77.7-99.8). In outpatient COVID-19 cases sensitivity was significantly lower in the VT-assay (86.2%, CI(95%) 74.8-93.1) compared with the EI-assay (98.5%, CI(95%) 90.6-99.9). Assays for IgA and IgM demonstrated a lack of specificity or sensitivity. CONCLUSIONS: Our results indicate that SARS-CoV-2 serological assays may need to be optimized to produce reliable results in outpatient COVID-19 cases who are low or even asymptomatic. Assays for IgA and IgM have limited diagnostic performance and do not prove an additional value for population-based screening approaches. Twit Text FOAVip Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases ????Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=33159952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33159952 #FOAvip English Wikipedia <ref>{{Cite pmid|33159952}}</ref> Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases #MMPMID33159952 Wolf J; Kaiser T; Pehnke S; Nickel O; Lubbert C; Kalbitz S; Arnold B; Ermisch J; Berger L; Schroth S; Isermann B; Borte S; Biemann R Clin Chim Acta 2020[Dec]; 511 (ä): 352-359 PMID33159952show ga BACKGROUND: Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays differ in the target antigen specificity, e.g. of antibodies directed against the viral spike or the nucleocapsid protein, and in the spectrum of detected immunoglobulins. The aim of the study was to evaluate the performance of two different routinely used immunoassays in hospitalized and outpatient COVID-19 cases. METHODS: The test characteristics of commercially available spike1 protein-based serological assays (Euroimmun, EI-assays), determining IgA or IgG and nucleocapsid-based assays (Virotech, VT-assays) determining IgA, IgM or IgG were compared in 139 controls and 116 hospitalized and outpatient COVID-19 cases. RESULTS: Hospitalized COVID-19 patients (n = 51; 115 samples) showed significantly higher concentrations of antibodies against SARS-CoV-2 and differed from outpatient cases (n = 65) by higher age, higher disease severity scores and earlier follow up blood sampling. Sensitivity of the two IgG assays was comparable in hospitalized patients tested >/= 14 days (EI-assay: 88%, CI(95%) 67.6-99.9; VT-assay: 96%, CI(95%) 77.7-99.8). In outpatient COVID-19 cases sensitivity was significantly lower in the VT-assay (86.2%, CI(95%) 74.8-93.1) compared with the EI-assay (98.5%, CI(95%) 90.6-99.9). Assays for IgA and IgM demonstrated a lack of specificity or sensitivity. CONCLUSIONS: Our results indicate that SARS-CoV-2 serological assays may need to be optimized to produce reliable results in outpatient COVID-19 cases who are low or even asymptomatic. Assays for IgA and IgM have limited diagnostic performance and do not prove an additional value for population-based screening approaches. |*Hospitalization[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Ambulatory Care/methods/*standards[MESH] |COVID-19 Serological Testing/methods/*standards[MESH] |COVID-19/*blood/*diagnosis[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*isolation & purification[MESH]Differences of SARS-CoV-2 serological test performance between hospita(epmc).pdf DeepDyve Pubget Overpricing