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10.1007/s10787-020-00773-9

http://scihub22266oqcxt.onion/10.1007/s10787-020-00773-9
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33159646!7648206!33159646
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suck abstract from ncbi


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pmid33159646      Inflammopharmacology 2021 ; 29 (1): 91-100
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  • The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients #MMPMID33159646
  • Hariharan A; Hakeem AR; Radhakrishnan S; Reddy MS; Rela M
  • Inflammopharmacology 2021[Feb]; 29 (1): 91-100 PMID33159646show ga
  • Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute respiratory distress syndrome (ARDS) have been associated with the post-viral activation and release of cytokine/chemokines which leads to a "cytokine storm" causing inflammatory response and destruction, mainly affecting the lungs. COVID-19 activation of transcription factor, NF-kappa B (NF-kappaB) in various cells such as macrophages of lung, liver, kidney, central nervous system, gastrointestinal system and cardiovascular system leads to production of IL-1, IL-2, IL-6, IL-12, TNF-alpha, LT-alpha, LT-beta, GM-CSF, and various chemokines. The sensitised NF-kappaB in elderly and in patients with metabolic syndrome makes this set of population susceptible to COVID-19 and their worse complications, including higher mortality. Immunomodulation at the level of NF-kappaB activation and inhibitors of NF-kappaB (IkappaB) degradation along with TNF-alpha inhibition will potentially result in a reduction in the cytokine storm and alleviate the severity of COVID-19. Inhibition of NF-kappaB pathway has a potential therapeutic role in alleviating the severe form of COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*SARS-CoV-2[MESH]
  • |Aging/immunology[MESH]
  • |COVID-19/complications/immunology[MESH]
  • |Cytokine Release Syndrome/*prevention & control[MESH]
  • |Glucocorticoids/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Metabolic Syndrome/immunology[MESH]
  • |NF-kappa B/*antagonists & inhibitors/immunology[MESH]
  • |Respiratory Distress Syndrome/*drug therapy/etiology/immunology[MESH]
  • |Severity of Illness Index[MESH]
  • |Sex Characteristics[MESH]


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