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10.1007/s00403-020-02156-0 http://scihub22266oqcxt.onion/10.1007/s00403-020-02156-0 33159236!7646711!33159236     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Dermatol+Res 2021 ; 313 (8): 611-622 Nephropedia Template TP {{tp|p=33159236|t=2021. Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |pdf=|usr=}}{{33159236}} gab.com Text Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations JO: Arch Dermatol Res http://www.kidney.de/pget.php?&tw=1&pmid=33159236 #FOAvip The human infection caused by the novel SARS-CoV-2 is a public health emergency of international concern. Although the disease associated to this virus, named COVID-19, mainly affects the lungs, the infection can spread to extrapulmonary tissues, causing multiorgan involvement in severely ill patients. The broad infective capacity of SARS-CoV-2 is related to the pattern of expression of the viral entry factors ACE2 and TMPRSS2 in human tissues. As such, the respiratory and gastrointestinal tracts are at high risk for SARS-CoV-2 infection due to their high expression of ACE2 and TMPRSS2, which explains the clinical phenotype described in the vast majority of infected patients that includes pneumonia and diarrhea. Recently, preoccupation about the potential of the virus to infect the skin has been raised by dermatologists due to the increasing observations of cutaneous manifestations in patients with SARS-CoV-2 infection. Although there is little evidence of the expression of ACE2 and TMPRSS2 in the normal skin, the dermatological findings observed among COVID-19 patients warrants further investigation to delineate the mechanisms of skin affection after SARS-CoV-2 infection. Here, we provide a summary of the dermatological findings observed among patients with laboratory-confirmed SARS-CoV-2 infection based on recent reports. In addition, we analyze possible mechanisms of skin injury in COVID-19 patients and discuss about the risk of individuals with chronic skin conditions for SARS-CoV-2 infection. The present review constitutes a useful informative tool to improve our understanding of the pathophysiological mechanisms of COVID-19 and the possible implications of the current pandemic in dermatology. Twit Text FOAVip Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations ????Arch Dermatol Res http://www.kidney.de/pget.php?&tw=1&pmid=33159236 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33159236 #FOAvip English Wikipedia <ref>{{Cite pmid|33159236}}</ref> Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations #MMPMID33159236 Garduno-Soto M; Choreno-Parra JA; Cazarin-Barrientos J Arch Dermatol Res 2021[Oct]; 313 (8): 611-622 PMID33159236show ga The human infection caused by the novel SARS-CoV-2 is a public health emergency of international concern. Although the disease associated to this virus, named COVID-19, mainly affects the lungs, the infection can spread to extrapulmonary tissues, causing multiorgan involvement in severely ill patients. The broad infective capacity of SARS-CoV-2 is related to the pattern of expression of the viral entry factors ACE2 and TMPRSS2 in human tissues. As such, the respiratory and gastrointestinal tracts are at high risk for SARS-CoV-2 infection due to their high expression of ACE2 and TMPRSS2, which explains the clinical phenotype described in the vast majority of infected patients that includes pneumonia and diarrhea. Recently, preoccupation about the potential of the virus to infect the skin has been raised by dermatologists due to the increasing observations of cutaneous manifestations in patients with SARS-CoV-2 infection. Although there is little evidence of the expression of ACE2 and TMPRSS2 in the normal skin, the dermatological findings observed among COVID-19 patients warrants further investigation to delineate the mechanisms of skin affection after SARS-CoV-2 infection. Here, we provide a summary of the dermatological findings observed among patients with laboratory-confirmed SARS-CoV-2 infection based on recent reports. In addition, we analyze possible mechanisms of skin injury in COVID-19 patients and discuss about the risk of individuals with chronic skin conditions for SARS-CoV-2 infection. The present review constitutes a useful informative tool to improve our understanding of the pathophysiological mechanisms of COVID-19 and the possible implications of the current pandemic in dermatology. |*SARS-CoV-2[MESH] |COVID-19/*complications[MESH] |Gene Expression Regulation/physiology[MESH] |Humans[MESH] |Skin Diseases/*etiology/pathology[MESH] |Viral Tropism[MESH]Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifes(epmc).pdf DeepDyve Pubget Overpricing