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10.1038/s41422-020-00435-z http://scihub22266oqcxt.onion/10.1038/s41422-020-00435-z 33159154!7646495!33159154     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2020 ; 30 (12): 1078-1087 Nephropedia Template TP {{tp|p=33159154|t=2020. Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19 |pdf=|usr=}}{{33159154}} gab.com Text Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19 JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=33159154 #FOAvip Silent hypoxia has emerged as a unique feature of coronavirus disease 2019 (COVID-19). In this study, we show that mucins are accumulated in the bronchoalveolar lavage fluid (BALF) of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected mice and macaques. We find that induction of either interferon (IFN)-beta or IFN-gamma upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor (AhR) signaling through an IDO-Kyn-dependent pathway, leading to transcriptional upregulation of the expression of mucins, both the secreted and membrane-bound, in alveolar epithelial cells. Consequently, accumulated alveolar mucus affects the blood-gas barrier, thus inducing hypoxia and diminishing lung capacity, which can be reversed by blocking AhR activity. These findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the AhR pathway. Twit Text FOAVip Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19 ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=33159154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33159154 #FOAvip English Wikipedia <ref>{{Cite pmid|33159154}}</ref> Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19 #MMPMID33159154 Liu Y; Lv J; Liu J; Li M; Xie J; Lv Q; Deng W; Zhou N; Zhou Y; Song J; Wang P; Qin C; Tong WM; Huang B Cell Res 2020[Dec]; 30 (12): 1078-1087 PMID33159154show ga Silent hypoxia has emerged as a unique feature of coronavirus disease 2019 (COVID-19). In this study, we show that mucins are accumulated in the bronchoalveolar lavage fluid (BALF) of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected mice and macaques. We find that induction of either interferon (IFN)-beta or IFN-gamma upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor (AhR) signaling through an IDO-Kyn-dependent pathway, leading to transcriptional upregulation of the expression of mucins, both the secreted and membrane-bound, in alveolar epithelial cells. Consequently, accumulated alveolar mucus affects the blood-gas barrier, thus inducing hypoxia and diminishing lung capacity, which can be reversed by blocking AhR activity. These findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the AhR pathway. |Animals[MESH] |COVID-19/pathology/virology[MESH] |Cell Line[MESH] |Epithelial Cells/cytology/metabolism/virology[MESH] |Humans[MESH] |Hypoxia[MESH] |Interferon-beta/pharmacology[MESH] |Interferon-gamma/pharmacology[MESH] |Interferons/*metabolism[MESH] |Lung/metabolism/pathology[MESH] |Macaca[MESH] |Mice[MESH] |Mice, Inbred ICR[MESH] |Mice, Transgenic[MESH] |Mucins/metabolism[MESH] |Mucus/*metabolism[MESH] |Receptors, Aryl Hydrocarbon/*metabolism[MESH] |SARS-CoV-2/isolation & purification/pathogenicity[MESH] |Signal Transduction[MESH]Mucus production stimulated by IFN-AhR signaling triggers hypoxia of C(epmc).pdf DeepDyve Pubget Overpricing