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10.1126/science.abe1107 http://scihub22266oqcxt.onion/10.1126/science.abe1107 33159009!7857411!33159009     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 370 (6522): 1339-1343 Nephropedia Template TP {{tp|p=33159009|t=2020. Preexisting and de novo humoral immunity to SARS-CoV-2 in humans |pdf=|usr=}}{{33159009}} gab.com Text Preexisting and de novo humoral immunity to SARS-CoV-2 in humans JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33159009 #FOAvip Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable using a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. They were predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit. By contrast, SARS-CoV-2 infection induced higher titers of SARS-CoV-2 S-reactive IgG antibodies targeting both the S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation period. SARS-CoV-2-uninfected donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes. Distinguishing preexisting and de novo immunity will be critical for our understanding of susceptibility to and the natural course of SARS-CoV-2 infection. Twit Text FOAVip Preexisting and de novo humoral immunity to SARS-CoV-2 in humans ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33159009 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33159009 #FOAvip English Wikipedia <ref>{{Cite pmid|33159009}}</ref> Preexisting and de novo humoral immunity to SARS-CoV-2 in humans #MMPMID33159009 Ng KW; Faulkner N; Cornish GH; Rosa A; Harvey R; Hussain S; Ulferts R; Earl C; Wrobel AG; Benton DJ; Roustan C; Bolland W; Thompson R; Agua-Doce A; Hobson P; Heaney J; Rickman H; Paraskevopoulou S; Houlihan CF; Thomson K; Sanchez E; Shin GY; Spyer MJ; Joshi D; O'Reilly N; Walker PA; Kjaer S; Riddell A; Moore C; Jebson BR; Wilkinson M; Marshall LR; Rosser EC; Radziszewska A; Peckham H; Ciurtin C; Wedderburn LR; Beale R; Swanton C; Gandhi S; Stockinger B; McCauley J; Gamblin SJ; McCoy LE; Cherepanov P; Nastouli E; Kassiotis G Science 2020[Dec]; 370 (6522): 1339-1343 PMID33159009show ga Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable using a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. They were predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit. By contrast, SARS-CoV-2 infection induced higher titers of SARS-CoV-2 S-reactive IgG antibodies targeting both the S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation period. SARS-CoV-2-uninfected donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes. Distinguishing preexisting and de novo immunity will be critical for our understanding of susceptibility to and the natural course of SARS-CoV-2 infection. |*Immunity, Humoral[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Antibodies, Viral/*blood[MESH] |COVID-19/blood/*immunology[MESH] |Epitope Mapping[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunoglobulin A/blood[MESH] |Immunoglobulin G/blood[MESH] |Immunoglobulin M/blood[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/chemistry/*immunology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*immunology[MESH] |Viral Zoonoses/blood/immunology[MESH]Preexisting and de novo humoral immunity to SARS-CoV-2 in humans (epmc).pdf DeepDyve Pubget Overpricing