Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/sciimmunol.abc4557 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abc4557 33158975!7970412!33158975     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2020 ; 5 (53): ä Nephropedia Template TP {{tp|p=33158975|t=2020. Tissue-resident CD8(+) T cells drive age-associated chronic lung sequelae after viral pneumonia |pdf=|usr=}}{{33158975}} gab.com Text Tissue-resident CD8(+) T cells drive age-associated chronic lung sequelae after viral pneumonia JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33158975 #FOAvip Lower respiratory viral infections, such as influenza virus and severe acute respiratory syndrome coronavirus 2 infections, often cause severe viral pneumonia in aged individuals. Here, we report that influenza viral pneumonia leads to chronic nonresolving lung pathology and exacerbated accumulation of CD8(+) tissue-resident memory T cells (T(RM)) in the respiratory tract of aged hosts. T(RM) cell accumulation relies on elevated TGF-beta present in aged tissues. Further, we show that T(RM) cells isolated from aged lungs lack a subpopulation characterized by expression of molecules involved in TCR signaling and effector function. Consequently, T(RM) cells from aged lungs were insufficient to provide heterologous protective immunity. The depletion of CD8(+) T(RM) cells dampens persistent chronic lung inflammation and ameliorates tissue fibrosis in aged, but not young, animals. Collectively, our data demonstrate that age-associated T(RM) cell malfunction supports chronic lung inflammatory and fibrotic sequelae after viral pneumonia. Twit Text FOAVip Tissue-resident CD8(+) T cells drive age-associated chronic lung sequelae after viral pneumonia ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33158975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33158975 #FOAvip English Wikipedia <ref>{{Cite pmid|33158975}}</ref> Tissue-resident CD8(+) T cells drive age-associated chronic lung sequelae after viral pneumonia #MMPMID33158975 Goplen NP; Wu Y; Son YM; Li C; Wang Z; Cheon IS; Jiang L; Zhu B; Ayasoufi K; Chini EN; Johnson AJ; Vassallo R; Limper AH; Zhang N; Sun J Sci Immunol 2020[Nov]; 5 (53): ä PMID33158975show ga Lower respiratory viral infections, such as influenza virus and severe acute respiratory syndrome coronavirus 2 infections, often cause severe viral pneumonia in aged individuals. Here, we report that influenza viral pneumonia leads to chronic nonresolving lung pathology and exacerbated accumulation of CD8(+) tissue-resident memory T cells (T(RM)) in the respiratory tract of aged hosts. T(RM) cell accumulation relies on elevated TGF-beta present in aged tissues. Further, we show that T(RM) cells isolated from aged lungs lack a subpopulation characterized by expression of molecules involved in TCR signaling and effector function. Consequently, T(RM) cells from aged lungs were insufficient to provide heterologous protective immunity. The depletion of CD8(+) T(RM) cells dampens persistent chronic lung inflammation and ameliorates tissue fibrosis in aged, but not young, animals. Collectively, our data demonstrate that age-associated T(RM) cell malfunction supports chronic lung inflammatory and fibrotic sequelae after viral pneumonia. |Age Factors[MESH] |Animals[MESH] |CD8-Positive T-Lymphocytes/*immunology/metabolism/virology[MESH] |COVID-19/*immunology/metabolism/virology[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Immunologic Memory/*immunology[MESH] |Influenza, Human/immunology/metabolism/virology[MESH] |Lung/*immunology/metabolism/virology[MESH] |Mice, Inbred C57BL[MESH] |Orthomyxoviridae Infections/immunology/metabolism/virology[MESH] |Orthomyxoviridae/immunology/physiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/metabolism/virology[MESH] |SARS-CoV-2/*immunology/physiology[MESH]Tissue-resident CD8(+) T cells drive age-associated chronic lung seque(epmc).pdf DeepDyve Pubget Overpricing