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10.1016/j.ijid.2020.10.093

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.10.093
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33157292!7607231!33157292
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suck abstract from ncbi


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pmid33157292      Int+J+Infect+Dis 2021 ; 102 (ä): 529-531
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  • Potential mechanisms of nafamostat therapy for severe COVID-19 pneumonia with disseminated intravascular coagulation #MMPMID33157292
  • Takahashi W; Yoneda T; Koba H; Ueda T; Tsuji N; Ogawa H; Asakura H
  • Int J Infect Dis 2021[Jan]; 102 (ä): 529-531 PMID33157292show ga
  • Nafamostat, a serine proteinase inhibitor with various actions including antithrombin, antiplasmin, and antitrypsin effects, has been used in clinical practice to treat disseminated intravascular coagulation (DIC) and pancreatitis. This case report describes the clinical course of a patient with COVID-19 pneumonia whose severe hypoxemia, probably caused by DIC and pulmonary embolism, showed remarkable improvement with combination heparin and nafamostat therapy. In addition, beneficial mechanisms of nafamostat against COVID-19 and the necessity of attention to hyperkalemia as an adverse effect are discussed.
  • |Aged[MESH]
  • |Anticoagulants/*administration & dosage[MESH]
  • |Benzamidines[MESH]
  • |Blood Coagulation/drug effects[MESH]
  • |COVID-19/blood/*complications/virology[MESH]
  • |Disseminated Intravascular Coagulation/blood/*drug therapy/etiology/virology[MESH]
  • |Guanidines/*administration & dosage[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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