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10.1016/j.cell.2020.10.039 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.10.039 33157038!7590812!33157038     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (6): 1520-1535.e14 Nephropedia Template TP {{tp|p=33157038|t=2020. beta-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway |pdf=|usr=}}{{33157038}} gab.com Text beta-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33157038 #FOAvip beta-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is known regarding their cellular entry and replication pathways, but their mode of egress remains uncertain. Using imaging methodologies and virus-specific reporters, we demonstrate that beta-coronaviruses utilize lysosomal trafficking for egress rather than the biosynthetic secretory pathway more commonly used by other enveloped viruses. This unconventional egress is regulated by the Arf-like small GTPase Arl8b and can be blocked by the Rab7 GTPase competitive inhibitor CID1067700. Such non-lytic release of beta-coronaviruses results in lysosome deacidification, inactivation of lysosomal degradation enzymes, and disruption of antigen presentation pathways. beta-Coronavirus-induced exploitation of lysosomal organelles for egress provides insights into the cellular and immunological abnormalities observed in patients and suggests new therapeutic modalities. Twit Text FOAVip beta-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33157038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33157038 #FOAvip English Wikipedia <ref>{{Cite pmid|33157038}}</ref> beta-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway #MMPMID33157038 Ghosh S; Dellibovi-Ragheb TA; Kerviel A; Pak E; Qiu Q; Fisher M; Takvorian PM; Bleck C; Hsu VW; Fehr AR; Perlman S; Achar SR; Straus MR; Whittaker GR; de Haan CAM; Kehrl J; Altan-Bonnet G; Altan-Bonnet N Cell 2020[Dec]; 183 (6): 1520-1535.e14 PMID33157038show ga beta-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is known regarding their cellular entry and replication pathways, but their mode of egress remains uncertain. Using imaging methodologies and virus-specific reporters, we demonstrate that beta-coronaviruses utilize lysosomal trafficking for egress rather than the biosynthetic secretory pathway more commonly used by other enveloped viruses. This unconventional egress is regulated by the Arf-like small GTPase Arl8b and can be blocked by the Rab7 GTPase competitive inhibitor CID1067700. Such non-lytic release of beta-coronaviruses results in lysosome deacidification, inactivation of lysosomal degradation enzymes, and disruption of antigen presentation pathways. beta-Coronavirus-induced exploitation of lysosomal organelles for egress provides insights into the cellular and immunological abnormalities observed in patients and suggests new therapeutic modalities. |*Secretory Pathway[MESH] |*Virus Release[MESH] |ADP-Ribosylation Factors/metabolism[MESH] |Animals[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*metabolism/pathology[MESH] |Female[MESH] |HeLa Cells[MESH] |Heterocyclic Compounds, 2-Ring/pharmacology[MESH] |Humans[MESH] |Lysosomes[MESH] |Mice[MESH] |SARS-CoV-2/*metabolism[MESH] |Thiourea/analogs & derivatives/pharmacology[MESH] |rab GTP-Binding Proteins/antagonists & inhibitors/metabolism[MESH]beta-Coronaviruses Use Lysosomes for Egress Instead of the Biosyntheti(epmc).pdf DeepDyve Pubget Overpricing