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10.7554/eLife.61562 http://scihub22266oqcxt.onion/10.7554/eLife.61562 33155980!7647404!33155980     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=33155980|t=2020. Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans |pdf=|usr=}}{{33155980}} gab.com Text Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33155980 #FOAvip Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan villages where pig husbandry is rare. Notably, the majority of these worms (63/68) possessed mitochondrial genomes that clustered closer to the pig parasite Ascaris suum than to A. lumbricoides. Comparative phylogenomic analyses identified over 11 million nuclear-encoded SNPs but just two distinct genetic types that had recombined across the genomes analyzed. The nuclear genomes had extensive heterozygosity, and all samples existed as genetic mosaics with either A. suum-like or A. lumbricoides-like inheritance patterns supporting a highly interbred Ascaris species genetic complex. As no barriers appear to exist for anthroponotic transmission of these 'hybrid' worms, a one-health approach to control the spread of human ascariasis will be necessary. Twit Text FOAVip Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33155980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33155980 #FOAvip English Wikipedia <ref>{{Cite pmid|33155980}}</ref> Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans #MMPMID33155980 Easton A; Gao S; Lawton SP; Bennuru S; Khan A; Dahlstrom E; Oliveira RG; Kepha S; Porcella SF; Webster J; Anderson R; Grigg ME; Davis RE; Wang J; Nutman TB Elife 2020[Nov]; 9 (ä): ä PMID33155980show ga Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan villages where pig husbandry is rare. Notably, the majority of these worms (63/68) possessed mitochondrial genomes that clustered closer to the pig parasite Ascaris suum than to A. lumbricoides. Comparative phylogenomic analyses identified over 11 million nuclear-encoded SNPs but just two distinct genetic types that had recombined across the genomes analyzed. The nuclear genomes had extensive heterozygosity, and all samples existed as genetic mosaics with either A. suum-like or A. lumbricoides-like inheritance patterns supporting a highly interbred Ascaris species genetic complex. As no barriers appear to exist for anthroponotic transmission of these 'hybrid' worms, a one-health approach to control the spread of human ascariasis will be necessary. |Animals[MESH] |Ascariasis/*parasitology/veterinary[MESH] |Ascaris lumbricoides/*genetics/pathogenicity[MESH] |Ascaris suum/*genetics/pathogenicity[MESH] |Cyclooxygenase 1/genetics[MESH] |Female[MESH] |Genome, Helminth/genetics[MESH] |Genome, Mitochondrial/genetics[MESH] |Heterozygote[MESH] |Humans[MESH] |Hybridization, Genetic/genetics[MESH] |Kenya[MESH] |Male[MESH] |Phylogeny[MESH] |Polymorphism, Single Nucleotide/genetics[MESH] |Proteome/genetics[MESH] |Swine[MESH]Molecular evidence of hybridization between pig and human Ascaris indi(epmc).pdf DeepDyve Pubget Overpricing