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Curr Pharm Des 2021[]; 27 (13): 1579-1587 PMID33155905show ga
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has changed the global scenario. To date, there are no treatment or preventive options. The discovery of a new drug will take time. In addition, the new drug will have side effects, and the virus will gradually become resistant to it. Therefore, it is important to search for a drug with a natural origin. OBJECTIVE: In this review, we analyzed and summarized various ethnomedicinal plants and their bioactive compounds as a source of antiviral agents for COVID-19 prevention and treatment. METHODS: From the literature, we selected different natural compounds that can act as potential targets at low cost with broad-spectrum antiviral activity. RESULTS: Of the 200 Chinese herbal extracts tested for their possible role against SARS-CoV, Lycoris radiata, Artemisia annua, Pyrrosia lingua, and Lindera aggregate showed anti-SARS-CoV effects with the median effective concentration = 2.4-88.2 mug/mL. CONCLUSION: Ethnomedicinal herbs can be used as an alternative source of novel, promising antiviral agents that might directly or indirectly inhibit the COVID-19 progression.
Curr+Pharm+Des 2021 ; 27 (13): 1579-1587
