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10.3389/fmed.2020.562142

http://scihub22266oqcxt.onion/10.3389/fmed.2020.562142
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33154972!7586311!33154972
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suck abstract from ncbi


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pmid33154972      Front+Med+(Lausanne) 2020 ; 7 (ä): 562142
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  • Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic #MMPMID33154972
  • Stradner MH; Dejaco C; Zwerina J; Fritsch-Stork RD
  • Front Med (Lausanne) 2020[]; 7 (ä): 562142 PMID33154972show ga
  • In December 2019, a cluster of severe pneumonia was observed in China, with the subsequent discovery of a new beta-coronavirus (SARS-CoV-2) as the causative agent. The elicited disease COVID-19 is characterized by fever, dry cough, myalgia, or fatigue and has a favorable outcome in the majority of cases. However, in some patients COVID-19 leads to severe pneumonia and sepsis with subsequent respiratory failure and gastrointestinal, hematological, neurological, and cardiovascular complications. A higher risk of infection is intrinsic to active rheumatic and musculoskeletal diseases (RMD) and the use of biological disease modifying anti-rheumatic drugs (DMARDs). With an increasing number of reports on COVID-19 in RMD patients, we are beginning to appraise their risks. In this review, we summarize the published cases of COVID-19 infections in RMD patients, including patients with inflammatory arthritis and connective tissue diseases as well as anti-phospholipid syndrome and Kawasaki syndrome. Overall, patients with inflammatory arthritis do not seem to be at a higher risk for infection or a severe course of COVID-19. Risk for critical COVID-19 in patients with systemic inflammatory diseases such as SLE or vasculitis might be increased, but this needs further confirmation. Furthermore, we summarize the data on DMARDs used to fight SARS-CoV-2 infection and hyperinflammation.
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