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10.3389/fimmu.2020.573339

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.573339
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33154751!7586316!33154751
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suck abstract from ncbi


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pmid33154751      Front+Immunol 2020 ; 11 (ä): 573339
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  • Coronavirus Proteins as Ion Channels: Current and Potential Research #MMPMID33154751
  • McClenaghan C; Hanson A; Lee SJ; Nichols CG
  • Front Immunol 2020[]; 11 (ä): 573339 PMID33154751show ga
  • Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to their exceptional zoonotic potential - a feature arising from their ability to infect a diverse range of potential hosts combined with their high capacity for mutation and recombination. After Severe Acute Respiratory Syndrome (SARS) CoV-1 in 2003 and Middle East Respiratory Syndrome (MERS) CoV in 2012, with the current SARS-CoV-2 pandemic we are now in the midst of the third deadly international CoV outbreak in less than 20 years. Coronavirus outbreaks present a critical threat to global public health and an urgent necessity for therapeutic options. Here, we critically examine the current evidence for ion channel activity in CoV proteins and the potential for modulation as a therapeutic approach.
  • |Animals[MESH]
  • |Humans[MESH]
  • |Ion Channels/genetics/*metabolism[MESH]
  • |Severe Acute Respiratory Syndrome/*virology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/genetics/*metabolism[MESH]
  • |Viral Envelope Proteins/genetics/metabolism[MESH]
  • |Viral Proteins/genetics/*metabolism[MESH]


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