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10.1016/j.it.2020.10.005

http://scihub22266oqcxt.onion/10.1016/j.it.2020.10.005
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33153908!7561287!33153908
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suck abstract from ncbi


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pmid33153908      Trends+Immunol 2020 ; 41 (12): 1083-1099
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  • Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines #MMPMID33153908
  • Lee S; Channappanavar R; Kanneganti TD
  • Trends Immunol 2020[Dec]; 41 (12): 1083-1099 PMID33153908show ga
  • The innate immune system acts as the first line of defense against pathogens, including coronaviruses (CoVs). Severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV are epidemic zoonotic CoVs that emerged at the beginning of the 21st century. The recently emerged virus SARS-CoV-2 is a novel strain of CoV that has caused the coronavirus 2019 (COVID-19) pandemic. Scientific advancements made by studying the SARS-CoV and MERS-CoV outbreaks have provided a foundation for understanding pathogenesis and innate immunity against SARS-CoV-2. In this review, we focus on our present understanding of innate immune responses, inflammasome activation, inflammatory cell death pathways, and cytokine secretion during SARS-CoV, MERS-CoV, and SARS-CoV-2 infection. We also discuss how the pathogenesis of these viruses influences these biological processes.
  • |Animals[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cell Death/*immunology[MESH]
  • |Cytokines/*immunology[MESH]
  • |Humans[MESH]
  • |Immunity, Innate/*immunology[MESH]
  • |Inflammasomes/*immunology[MESH]


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