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10.1016/j.chom.2020.09.016 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.09.016 33152279!7528903!33152279     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2020 ; 28 (5): 646-659 Nephropedia Template TP {{tp|p=33152279|t=2020. ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics |pdf=|usr=}}{{33152279}} gab.com Text ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33152279 #FOAvip The Preclinical Working Group of Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV), a public-private partnership spearheaded by the National Institutes of Health, has been charged with identifying, prioritizing, and communicating SARS-CoV-2 preclinical resources. Reviewing SARS-CoV-2 animal model data facilitates standardization and harmonization and informs knowledge gaps and prioritization of limited resources. To date, mouse, hamster, ferret, guinea pig, and non-human primates have been investigated. Several species are permissive for SARS-CoV-2 replication, often exhibiting mild disease with resolution, reflecting most human COVID-19 cases. More severe disease develops in a few models, some associated with advanced age, a risk factor for human disease. This review provides a snapshot that recommends the suitability of models for testing vaccines and therapeutics, which may evolve as our understanding of COVID-19 disease biology improves. COVID-19 is a complex disease, and individual models recapitulate certain aspects of disease; therefore, the coordination and assessment of animal models is imperative. Twit Text FOAVip ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33152279 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33152279 #FOAvip English Wikipedia <ref>{{Cite pmid|33152279}}</ref> ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics #MMPMID33152279 Hewitt JA; Lutz C; Florence WC; Pitt MLM; Rao S; Rappaport J; Haigwood NL Cell Host Microbe 2020[Nov]; 28 (5): 646-659 PMID33152279show ga The Preclinical Working Group of Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV), a public-private partnership spearheaded by the National Institutes of Health, has been charged with identifying, prioritizing, and communicating SARS-CoV-2 preclinical resources. Reviewing SARS-CoV-2 animal model data facilitates standardization and harmonization and informs knowledge gaps and prioritization of limited resources. To date, mouse, hamster, ferret, guinea pig, and non-human primates have been investigated. Several species are permissive for SARS-CoV-2 replication, often exhibiting mild disease with resolution, reflecting most human COVID-19 cases. More severe disease develops in a few models, some associated with advanced age, a risk factor for human disease. This review provides a snapshot that recommends the suitability of models for testing vaccines and therapeutics, which may evolve as our understanding of COVID-19 disease biology improves. COVID-19 is a complex disease, and individual models recapitulate certain aspects of disease; therefore, the coordination and assessment of animal models is imperative. |*Coronavirus[MESH] |*Coronavirus Infections/epidemiology[MESH] |*Pandemics/prevention & control[MESH] |*Pneumonia, Viral[MESH] |*Vaccines[MESH] |Animals[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Cricetinae[MESH] |Guinea Pigs[MESH] |Humans[MESH] |Mice[MESH]ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vac(epmc).pdf DeepDyve Pubget Overpricing