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10.1371/journal.pone.0241824

http://scihub22266oqcxt.onion/10.1371/journal.pone.0241824
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33152008!7644030!33152008
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suck abstract from ncbi


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pmid33152008      PLoS+One 2020 ; 15 (11): e0241824
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  • Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants #MMPMID33152008
  • Ho FK; Petermann-Rocha F; Gray SR; Jani BD; Katikireddi SV; Niedzwiedz CL; Foster H; Hastie CE; Mackay DF; Gill JMR; O'Donnell C; Welsh P; Mair F; Sattar N; Celis-Morales CA; Pell JP
  • PLoS One 2020[]; 15 (11): e0241824 PMID33152008show ga
  • INTRODUCTION: Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors. METHODS: In UK Biobank, a population cohort study, baseline data were linked to COVID-19 deaths. Poisson regression was used to study the association between current age and COVID-19 mortality. RESULTS: Among eligible participants, 438 (0.09%) died of COVID-19. Current age was associated exponentially with COVID-19 mortality. Overall, participants aged >/=75 years were at 13-fold (95% CI 9.13-17.85) mortality risk compared with those <65 years. Low forced expiratory volume in 1 second, high systolic blood pressure, low handgrip strength, and multiple long-term conditions were significant mediators, and collectively explained 39.3% of their excess risk. The associations between these risk factors and COVID-19 mortality were stronger among older participants. Participants aged >/=75 without additional risk factors were at 4-fold risk (95% CI 1.57-9.96, P = 0.004) compared with all participants aged <65 years. CONCLUSIONS: Higher COVID-19 mortality among older adults was partially explained by other risk factors. 'Healthy' older adults were at much lower risk. Nonetheless, older age was an independent risk factor for COVID-19 mortality.
  • |*Age Factors[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*mortality[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*mortality[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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