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10.3390/molecules25215088 http://scihub22266oqcxt.onion/10.3390/molecules25215088 33147821!7663370!33147821     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2020 ; 25 (21): ä Nephropedia Template TP {{tp|p=33147821|t=2020. Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2 |pdf=|usr=}}{{33147821}} gab.com Text Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2 JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33147821 #FOAvip With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has emerged as a promising threat to human health worldwide. Recently, the World Health Organization (WHO) has announced the infectious disease caused by SARS-CoV-2, which is known as coronavirus disease-2019 (COVID-2019), as a global pandemic. Additionally, the positive cases are still following an upward trend worldwide and as a corollary, there is a need for a potential vaccine to impede the progression of the disease. Lately, it has been documented that the nucleocapsid (N) protein of SARS-CoV-2 is responsible for viral replication and interferes with host immune responses. We comparatively analyzed the sequences of N protein of SARS-CoV-2 for the identification of core attributes and analyzed the ancestry through phylogenetic analysis. Subsequently, we predicted the most immunogenic epitope for the T-cell and B-cell. Importantly, our investigation mainly focused on major histocompatibility complex (MHC) class I potential peptides and NTASWFTAL interacted with most human leukocyte antigen (HLA) that are encoded by MHC class I molecules. Further, molecular docking analysis unveiled that NTASWFTAL possessed a greater affinity towards HLA and also available in a greater range of the population. Our study provides a consolidated base for vaccine design and we hope that this computational analysis will pave the way for designing novel vaccine candidates. Twit Text FOAVip Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2 ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33147821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33147821 #FOAvip English Wikipedia <ref>{{Cite pmid|33147821}}</ref> Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2 #MMPMID33147821 Rakib A; Sami SA; Islam MA; Ahmed S; Faiz FB; Khanam BH; Marma KKS; Rahman M; Uddin MMN; Nainu F; Emran TB; Simal-Gandara J Molecules 2020[Nov]; 25 (21): ä PMID33147821show ga With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has emerged as a promising threat to human health worldwide. Recently, the World Health Organization (WHO) has announced the infectious disease caused by SARS-CoV-2, which is known as coronavirus disease-2019 (COVID-2019), as a global pandemic. Additionally, the positive cases are still following an upward trend worldwide and as a corollary, there is a need for a potential vaccine to impede the progression of the disease. Lately, it has been documented that the nucleocapsid (N) protein of SARS-CoV-2 is responsible for viral replication and interferes with host immune responses. We comparatively analyzed the sequences of N protein of SARS-CoV-2 for the identification of core attributes and analyzed the ancestry through phylogenetic analysis. Subsequently, we predicted the most immunogenic epitope for the T-cell and B-cell. Importantly, our investigation mainly focused on major histocompatibility complex (MHC) class I potential peptides and NTASWFTAL interacted with most human leukocyte antigen (HLA) that are encoded by MHC class I molecules. Further, molecular docking analysis unveiled that NTASWFTAL possessed a greater affinity towards HLA and also available in a greater range of the population. Our study provides a consolidated base for vaccine design and we hope that this computational analysis will pave the way for designing novel vaccine candidates. |Amino Acid Sequence[MESH] |Betacoronavirus/*immunology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/immunology/prevention & control[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Drug Hypersensitivity/immunology[MESH] |Epitopes, B-Lymphocyte/immunology[MESH] |Epitopes, T-Lymphocyte/immunology[MESH] |Histocompatibility Antigens Class I[MESH] |Humans[MESH] |Models, Molecular[MESH] |Molecular Docking Simulation[MESH] |Nucleocapsid Proteins/chemistry/*immunology[MESH] |Peptide Fragments/immunology[MESH] |Phosphoproteins[MESH] |Protein Structure, Secondary[MESH] |SARS-CoV-2[MESH]Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Se(epmc).pdf DeepDyve Pubget Overpricing