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10.1016/j.celrep.2020.108339 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108339 33147451!7608022!33147451     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2020 ; 33 (5): 108339 Nephropedia Template TP {{tp|p=33147451|t=2020. HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon |pdf=|usr=}}{{33147451}} gab.com Text HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33147451 #FOAvip Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmitted via corneal transplantation in mice. However, in human corneal explants, we report that ZIKV does not replicate efficiently and that SARS-CoV-2 does not replicate at all. Additionally, we demonstrate that type III interferon (IFN-lambda) and its receptor (IFNlambdaR1) are expressed in the corneal epithelium. Treatment of human corneal explants with IFN-lambda, and treatment of mice with IFN-lambda eye drops, upregulates antiviral interferon-stimulated genes. In human corneal explants, blockade of IFNlambdaR1 enhances replication of ZIKV and HSV-1 but not SARS-CoV-2. In addition to an antiviral role for IFNlambdaR1 in the cornea, our results suggest that the human cornea does not support SARS-CoV-2 infection despite expression of ACE2, a SARS-CoV-2 receptor, in the human corneal epithelium. Twit Text FOAVip HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33147451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33147451 #FOAvip English Wikipedia <ref>{{Cite pmid|33147451}}</ref> HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon #MMPMID33147451 Miner JJ; Platt DJ; Ghaznavi CM; Chandra P; Santeford A; Menos AM; Dong Z; Wang ER; Qian W; Karozichian ES; Philips JA; Apte RS Cell Rep 2020[Nov]; 33 (5): 108339 PMID33147451show ga Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmitted via corneal transplantation in mice. However, in human corneal explants, we report that ZIKV does not replicate efficiently and that SARS-CoV-2 does not replicate at all. Additionally, we demonstrate that type III interferon (IFN-lambda) and its receptor (IFNlambdaR1) are expressed in the corneal epithelium. Treatment of human corneal explants with IFN-lambda, and treatment of mice with IFN-lambda eye drops, upregulates antiviral interferon-stimulated genes. In human corneal explants, blockade of IFNlambdaR1 enhances replication of ZIKV and HSV-1 but not SARS-CoV-2. In addition to an antiviral role for IFNlambdaR1 in the cornea, our results suggest that the human cornea does not support SARS-CoV-2 infection despite expression of ACE2, a SARS-CoV-2 receptor, in the human corneal epithelium. |Animals[MESH] |Betacoronavirus/immunology/*physiology[MESH] |COVID-19[MESH] |Cornea/immunology/*virology[MESH] |Coronavirus Infections/immunology/*transmission/virology[MESH] |Herpes Simplex/immunology/transmission/virology[MESH] |Herpesvirus 1, Human/*physiology[MESH] |Humans[MESH] |Interferon Lambda[MESH] |Interferons/*immunology[MESH] |Mice[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/*transmission/virology[MESH] |SARS-CoV-2[MESH] |Virus Replication/physiology[MESH] |Zika Virus Infection/immunology/transmission/virology[MESH]HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea (epmc).pdf DeepDyve Pubget Overpricing