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10.1152/ajplung.00355.2020

http://scihub22266oqcxt.onion/10.1152/ajplung.00355.2020
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33146564!7869955!33146564
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suck abstract from ncbi


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pmid33146564      Am+J+Physiol+Lung+Cell+Mol+Physiol 2021 ; 320 (1): L84-L98
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  • High-dimensional single-cell analysis reveals the immune characteristics of COVID-19 #MMPMID33146564
  • Shi W; Liu X; Cao Q; Ma P; Le W; Xie L; Ye J; Wen W; Tang H; Su W; Zheng Y; Liu Y
  • Am J Physiol Lung Cell Mol Physiol 2021[Jan]; 320 (1): L84-L98 PMID33146564show ga
  • Coronavirus disease 2019 (COVID-19), driven by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a global pandemic in March 2020. Pathogenic T cells and inflammatory monocytes are regarded as the central drivers of the cytokine storm associated with the severity of COVID-19. In this study, we explored the characteristic peripheral cellular profiles of patients with COVID-19 in both acute and convalescent phases by single-cell mass cytometry (CyTOF). Using a combination of algorithm-guided data analyses, we identified peripheral immune cell subsets in COVID-19 and revealed CD4(+) T-cell depletion, T-cell differentiation, plasma cell expansion, and the reduced antigen presentation capacity of innate immunity. Notably, COVID-19 induces a dysregulation in the balance of monocyte populations by the expansion of the monocyte subsets. Collectively, our results represent a high-dimensional, single-cell profile of the peripheral immune response to SARS-CoV-2 infection.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antigen Presentation/immunology[MESH]
  • |CD4-Positive T-Lymphocytes/cytology/*immunology[MESH]
  • |COVID-19/*immunology/pathology[MESH]
  • |Cytokine Release Syndrome/immunology/pathology[MESH]
  • |Cytokines/immunology[MESH]
  • |Dendritic Cells/cytology/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Killer Cells, Natural/cytology/immunology[MESH]
  • |Leukocytes, Mononuclear/cytology/*immunology[MESH]
  • |Lymphocyte Depletion[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Monocytes/cytology/*immunology[MESH]
  • |Plasma Cells/cytology[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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  • suck abstract from ncbi

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