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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Physiol+Lung+Cell+Mol+Physiol 2021 ; 320 (1): L84-L98 Nephropedia Template TP
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High-dimensional single-cell analysis reveals the immune characteristics of COVID-19 #MMPMID33146564
Shi W; Liu X; Cao Q; Ma P; Le W; Xie L; Ye J; Wen W; Tang H; Su W; Zheng Y; Liu Y
Am J Physiol Lung Cell Mol Physiol 2021[Jan]; 320 (1): L84-L98 PMID33146564show ga
Coronavirus disease 2019 (COVID-19), driven by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a global pandemic in March 2020. Pathogenic T cells and inflammatory monocytes are regarded as the central drivers of the cytokine storm associated with the severity of COVID-19. In this study, we explored the characteristic peripheral cellular profiles of patients with COVID-19 in both acute and convalescent phases by single-cell mass cytometry (CyTOF). Using a combination of algorithm-guided data analyses, we identified peripheral immune cell subsets in COVID-19 and revealed CD4(+) T-cell depletion, T-cell differentiation, plasma cell expansion, and the reduced antigen presentation capacity of innate immunity. Notably, COVID-19 induces a dysregulation in the balance of monocyte populations by the expansion of the monocyte subsets. Collectively, our results represent a high-dimensional, single-cell profile of the peripheral immune response to SARS-CoV-2 infection.