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10.1093/molbev/msaa281 http://scihub22266oqcxt.onion/10.1093/molbev/msaa281 33146390!7665640!33146390     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Evol 2021 ; 38 (4): 1241-1248 Nephropedia Template TP {{tp|p=33146390|t=2021. Characterizing Transcriptional Regulatory Sequences in Coronaviruses and Their Role in Recombination |pdf=|usr=}}{{33146390}} gab.com Text Characterizing Transcriptional Regulatory Sequences in Coronaviruses and Their Role in Recombination JO: Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=33146390 #FOAvip Novel coronaviruses, including SARS-CoV-2, SARS, and MERS, often originate from recombination events. The mechanism of recombination in RNA viruses is template switching. Coronavirus transcription also involves template switching at specific regions, called transcriptional regulatory sequences (TRS). It is hypothesized but not yet verified that TRS sites are prone to recombination events. Here, we developed a tool called SuPER to systematically identify TRS in coronavirus genomes and then investigated whether recombination is more common at TRS. We ran SuPER on 506 coronavirus genomes and identified 465 TRS-L and 3,509 TRS-B. We found that the TRS-L core sequence (CS) and the secondary structure of the leader sequence are generally conserved within coronavirus genera but different between genera. By examining the location of recombination breakpoints with respect to TRS-B CS, we observed that recombination hotspots are more frequently colocated with TRS-B sites than expected. Twit Text FOAVip Characterizing Transcriptional Regulatory Sequences in Coronaviruses and Their Role in Recombination ????Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=33146390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33146390 #FOAvip English Wikipedia <ref>{{Cite pmid|33146390}}</ref> Characterizing Transcriptional Regulatory Sequences in Coronaviruses and Their Role in Recombination #MMPMID33146390 Yang Y; Yan W; Hall AB; Jiang X Mol Biol Evol 2021[Apr]; 38 (4): 1241-1248 PMID33146390show ga Novel coronaviruses, including SARS-CoV-2, SARS, and MERS, often originate from recombination events. The mechanism of recombination in RNA viruses is template switching. Coronavirus transcription also involves template switching at specific regions, called transcriptional regulatory sequences (TRS). It is hypothesized but not yet verified that TRS sites are prone to recombination events. Here, we developed a tool called SuPER to systematically identify TRS in coronavirus genomes and then investigated whether recombination is more common at TRS. We ran SuPER on 506 coronavirus genomes and identified 465 TRS-L and 3,509 TRS-B. We found that the TRS-L core sequence (CS) and the secondary structure of the leader sequence are generally conserved within coronavirus genera but different between genera. By examining the location of recombination breakpoints with respect to TRS-B CS, we observed that recombination hotspots are more frequently colocated with TRS-B sites than expected. |*Genome, Viral[MESH] |*Recombination, Genetic[MESH] |*Regulatory Sequences, Nucleic Acid[MESH] |Coronavirus/*genetics[MESH] |Models, Genetic[MESH] |Nucleic Acid Conformation[MESH] |Phylogeny[MESH] |RNA, Messenger/genetics[MESH] |RNA, Viral/*genetics[MESH] |RNA-Seq[MESH] |SARS-CoV-2/*genetics[MESH]Characterizing Transcriptional Regulatory Sequences in Coronaviruses a(epmc).pdf DeepDyve Pubget Overpricing