Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-020-75929-2 http://scihub22266oqcxt.onion/10.1038/s41598-020-75929-2 33144670!7641273!33144670     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 18968 Nephropedia Template TP {{tp|p=33144670|t=2020. Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids |pdf=|usr=}}{{33144670}} gab.com Text Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33144670 #FOAvip The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the self-produced extracellular biofilm matrix confer high resistance to antibiotics, triggering infections difficult to treat. Therefore, novel antibiofilm strategies targeting matrix components are urgently needed. The Biofilm Associated Protein, Bap, expressed by staphylococcal species adopts functional amyloid-like structures as scaffolds of the biofilm matrix. In this work we have focused on identifying agents targeting Bap-related amyloid-like aggregates as a strategy to combat S. aureus biofilm-related infections. We identified that the flavonoids, quercetin, myricetin and scutellarein specifically inhibited Bap-mediated biofilm formation of S. aureus and other staphylococcal species. By using in vitro aggregation assays and the cell-based methodology for generation of amyloid aggregates based on the Curli-Dependent Amyloid Generator system (C-DAG), we demonstrated that these polyphenols prevented the assembly of Bap-related amyloid-like structures. Finally, using an in vivo catheter infection model, we showed that quercetin and myricetin significantly reduced catheter colonization by S. aureus. These results support the use of polyphenols as anti-amyloids molecules that can be used to treat biofilm-related infections. Twit Text FOAVip Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33144670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33144670 #FOAvip English Wikipedia <ref>{{Cite pmid|33144670}}</ref> Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids #MMPMID33144670 Matilla-Cuenca L; Gil C; Cuesta S; Rapun-Araiz B; Ziemyte M; Mira A; Lasa I; Valle J Sci Rep 2020[Nov]; 10 (1): 18968 PMID33144670show ga The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the self-produced extracellular biofilm matrix confer high resistance to antibiotics, triggering infections difficult to treat. Therefore, novel antibiofilm strategies targeting matrix components are urgently needed. The Biofilm Associated Protein, Bap, expressed by staphylococcal species adopts functional amyloid-like structures as scaffolds of the biofilm matrix. In this work we have focused on identifying agents targeting Bap-related amyloid-like aggregates as a strategy to combat S. aureus biofilm-related infections. We identified that the flavonoids, quercetin, myricetin and scutellarein specifically inhibited Bap-mediated biofilm formation of S. aureus and other staphylococcal species. By using in vitro aggregation assays and the cell-based methodology for generation of amyloid aggregates based on the Curli-Dependent Amyloid Generator system (C-DAG), we demonstrated that these polyphenols prevented the assembly of Bap-related amyloid-like structures. Finally, using an in vivo catheter infection model, we showed that quercetin and myricetin significantly reduced catheter colonization by S. aureus. These results support the use of polyphenols as anti-amyloids molecules that can be used to treat biofilm-related infections. |Amyloid/*metabolism[MESH] |Anti-Bacterial Agents/pharmacology[MESH] |Apigenin/pharmacology[MESH] |Bacterial Proteins/metabolism[MESH] |Biofilms/*drug effects[MESH] |Flavonoids/*pharmacology[MESH] |Quercetin/pharmacology[MESH]Antibiofilm activity of flavonoids on staphylococcal biofilms through (epmc).pdf DeepDyve Pubget Overpricing