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10.1074/jbc.REV120.013309 http://scihub22266oqcxt.onion/10.1074/jbc.REV120.013309 33144323!7948470!33144323     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2021 ; 296 (ä): 100017 Nephropedia Template TP {{tp|p=33144323|t=2021. Adaptation of influenza viruses to human airway receptors |pdf=|usr=}}{{33144323}} gab.com Text Adaptation of influenza viruses to human airway receptors JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=33144323 #FOAvip Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses. IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential. One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), which recognizes sialic-acid-containing glycans on host cells. HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the alpha2-6 configuration (NeuAcalpha2-6Gal). In contrast, HAs from avian viruses exhibit specificity for "avian-type" alpha2-3-linked (NeuAcalpha2-3Gal) receptors and thus require adaptive mutations to bind human-type receptors. Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic. This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources. In this review, we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs. Twit Text FOAVip Adaptation of influenza viruses to human airway receptors ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=33144323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33144323 #FOAvip English Wikipedia <ref>{{Cite pmid|33144323}}</ref> Adaptation of influenza viruses to human airway receptors #MMPMID33144323 Thompson AJ; Paulson JC J Biol Chem 2021[Jan]; 296 (ä): 100017 PMID33144323show ga Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses. IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential. One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), which recognizes sialic-acid-containing glycans on host cells. HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the alpha2-6 configuration (NeuAcalpha2-6Gal). In contrast, HAs from avian viruses exhibit specificity for "avian-type" alpha2-3-linked (NeuAcalpha2-3Gal) receptors and thus require adaptive mutations to bind human-type receptors. Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic. This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources. In this review, we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs. |*Pandemics[MESH] |Adaptation, Physiological[MESH] |Animals[MESH] |Binding Sites[MESH] |Biological Coevolution[MESH] |Birds/virology[MESH] |Hemagglutinin Glycoproteins, Influenza Virus/chemistry/genetics/*metabolism[MESH] |Humans[MESH] |Influenza A virus/chemistry/genetics/*metabolism[MESH] |Influenza in Birds/*epidemiology/transmission/virology[MESH] |Influenza, Human/*epidemiology/transmission/virology[MESH] |Models, Molecular[MESH] |Polysaccharides/*chemistry/metabolism[MESH] |Protein Binding[MESH] |Receptors, Virus/chemistry/genetics/*metabolism[MESH] |Respiratory System/virology[MESH] |Sialic Acids/chemistry/metabolism[MESH]Adaptation of influenza viruses to human airway receptors (epmc).pdf DeepDyve Pubget Overpricing