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10.3390/molecules25215052

http://scihub22266oqcxt.onion/10.3390/molecules25215052
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33143272!7662698!33143272
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suck abstract from ncbi

pmid33143272      Molecules 2020 ; 25 (21): ?
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  • Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies #MMPMID33143272
  • Korolenko TA; Johnston TP; Vetvicka V
  • Molecules 2020[Oct]; 25 (21): ? PMID33143272show ga
  • The concept of lysosomotropic agents significantly changed numerous aspects of cellular biochemistry, biochemical pharmacology, and clinical medicine. In the present review, we focused on numerous low-molecular and high-molecular lipophilic basic compounds and on the role of lipophagy and autophagy in experimental and clinical medicine. Attention was primarily focused on the most promising agents acting as autophagy inducers, which offer a new window for treatment and/or prophylaxis of various diseases, including type 2 diabetes mellitus, Parkinson's disease, and atherosclerosis. The present review summarizes current knowledge on the lysosomotropic features of medical drugs, as well as autophagy inducers, and their role in pathological processes.
  • |*Pharmaceutical Preparations[MESH]
  • |Animals[MESH]
  • |Atherosclerosis/*drug therapy/metabolism/pathology[MESH]
  • |Autophagy/*drug effects[MESH]
  • |Diabetes Mellitus, Type 2/*drug therapy/metabolism/pathology[MESH]
  • |Humans[MESH]


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