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10.3390/biomedicines8110462 http://scihub22266oqcxt.onion/10.3390/biomedicines8110462 33143053!7693865!33143053     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomedicines 2020 ; 8 (11): ä Nephropedia Template TP {{tp|p=33143053|t=2020. miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19 |pdf=|usr=}}{{33143053}} gab.com Text miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19 JO: Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=33143053 #FOAvip The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Here, we focused on the study of microRNAs that specifically target TMPRSS2. Through a bioinformatic approach, we identified miR-98-5p as a suitable candidate. Since we and others have shown that endothelial cells play a pivotal role in the pathogenesis of the coronavirus disease 2019 (COVID-19), we mechanistically validated miR-98-5p as a regulator of TMPRSS2 transcription in two different human endothelial cell types, derived from the lung and from the umbilical vein. Taken together, our findings indicate that TMPRSS2 represents a valid target in COVID-19 treatment, which may be achieved by specific non-coding-RNA approaches. Twit Text FOAVip miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19 ????Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=33143053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33143053 #FOAvip English Wikipedia <ref>{{Cite pmid|33143053}}</ref> miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19 #MMPMID33143053 Matarese A; Gambardella J; Sardu C; Santulli G Biomedicines 2020[Oct]; 8 (11): ä PMID33143053show ga The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Here, we focused on the study of microRNAs that specifically target TMPRSS2. Through a bioinformatic approach, we identified miR-98-5p as a suitable candidate. Since we and others have shown that endothelial cells play a pivotal role in the pathogenesis of the coronavirus disease 2019 (COVID-19), we mechanistically validated miR-98-5p as a regulator of TMPRSS2 transcription in two different human endothelial cell types, derived from the lung and from the umbilical vein. Taken together, our findings indicate that TMPRSS2 represents a valid target in COVID-19 treatment, which may be achieved by specific non-coding-RNA approaches. ämiR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Im(epmc).pdf DeepDyve Pubget Overpricing