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10.3390/ijms21218095 http://scihub22266oqcxt.onion/10.3390/ijms21218095 33142980!7662296!33142980     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (21): ä Nephropedia Template TP {{tp|p=33142980|t=2020. Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin |pdf=|usr=}}{{33142980}} gab.com Text Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33142980 #FOAvip For the last decade, porcine epidemic diarrhea virus (PEDV) variant strains have caused severe damage to the global pig industry. Until now, no effective antivirals have been developed for the therapeutic treatment of PEDV infection. In the present study, we found that quercetin significantly suppressed PEDV infection at noncytotoxic concentrations. A molecular docking study indicated that quercetin might bind the active site and binding pocket of PEDV 3C-like protease (3CL(pro)). Surface plasmon resonance (SPR) analysis revealed that quercetin exhibited a binding affinity to PEDV 3CL(pro). Based on the results of the fluorescence resonance energy transfer (FRET) assay, quercetin was proven to exert an inhibitory effect on PEDV 3CL(pro). Since coronavirus 3CL(pro) is an important drug target and participates in the viral replication process, quercetin should be developed as a novel drug in the control of PEDV infection. Twit Text FOAVip Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33142980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33142980 #FOAvip English Wikipedia <ref>{{Cite pmid|33142980}}</ref> Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin #MMPMID33142980 Li Z; Cao H; Cheng Y; Zhang X; Zeng W; Sun Y; Chen S; He Q; Han H Int J Mol Sci 2020[Oct]; 21 (21): ä PMID33142980show ga For the last decade, porcine epidemic diarrhea virus (PEDV) variant strains have caused severe damage to the global pig industry. Until now, no effective antivirals have been developed for the therapeutic treatment of PEDV infection. In the present study, we found that quercetin significantly suppressed PEDV infection at noncytotoxic concentrations. A molecular docking study indicated that quercetin might bind the active site and binding pocket of PEDV 3C-like protease (3CL(pro)). Surface plasmon resonance (SPR) analysis revealed that quercetin exhibited a binding affinity to PEDV 3CL(pro). Based on the results of the fluorescence resonance energy transfer (FRET) assay, quercetin was proven to exert an inhibitory effect on PEDV 3CL(pro). Since coronavirus 3CL(pro) is an important drug target and participates in the viral replication process, quercetin should be developed as a novel drug in the control of PEDV infection. |*Virus Replication[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology/therapeutic use[MESH] |Coronavirus 3C Proteases[MESH] |Coronavirus Infections/drug therapy/*veterinary[MESH] |Cysteine Endopeptidases[MESH] |Porcine epidemic diarrhea virus/*drug effects/physiology[MESH] |Quercetin/*pharmacology/therapeutic use[MESH] |Swine[MESH] |Swine Diseases/*drug therapy[MESH]Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C(epmc).pdf DeepDyve Pubget Overpricing