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10.1016/j.bioorg.2020.104326 http://scihub22266oqcxt.onion/10.1016/j.bioorg.2020.104326 33142431!7524440!33142431     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Chem 2020 ; 104 (ä): 104326 Nephropedia Template TP {{tp|p=33142431|t=2020. A perspective on potential target proteins of COVID-19: Comparison with SARS-CoV for designing new small molecules |pdf=|usr=}}{{33142431}} gab.com Text A perspective on potential target proteins of COVID-19: Comparison with SARS-CoV for designing new small molecules JO: Bioorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=33142431 #FOAvip SARS-CoV-2 (COVID-19) epidemic has created an unprecedented medical and economic crisis all over the world. SARS-CoV-2 is found to have more contagious character as compared to MERS-CoV and is spreading in a very fast manner all around the globe. It has affected over 31 million people all over the world till date. This virus shares around 80% of genome similarity with SARS-CoV. In this perspective, we have explored three major targets namely; SARS-CoV-2 spike (S) protein, RNA dependent RNA polymerase, and 3CL or M(pro) Protease for the inhibition of SARS-CoV-2. These targets have attracted attention of the medicinal chemists working on computer-aided drug design in developing new small molecules that might inhibit these targets for combating COVID-19 disease. Moreover, we have compared the similarity of these target proteins with earlier reported coronavirus (SARS-CoV). We have observed that both the coronaviruses share around 80% similarity in their amino acid sequence. The key amino acid interactions which can play a crucial role in designing new small molecule inhibitors against COVID-19 have been reported in this perspective. Authors believe that this study will help the medicinal chemists to understand the key amino acids essential for interactions at the active site of target proteins in SARS-CoV-2, based on their similarity with earlier reported viruses. In this review, we have also described the lead molecules under various clinical trials for their efficacy against COVID-19. Twit Text FOAVip A perspective on potential target proteins of COVID-19: Comparison with SARS-CoV for designing new small molecules ????Bioorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=33142431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33142431 #FOAvip English Wikipedia <ref>{{Cite pmid|33142431}}</ref> A perspective on potential target proteins of COVID-19: Comparison with SARS-CoV for designing new small molecules #MMPMID33142431 Kumar D; Chauhan G; Kalra S; Kumar B; Gill MS Bioorg Chem 2020[Nov]; 104 (ä): 104326 PMID33142431show ga SARS-CoV-2 (COVID-19) epidemic has created an unprecedented medical and economic crisis all over the world. SARS-CoV-2 is found to have more contagious character as compared to MERS-CoV and is spreading in a very fast manner all around the globe. It has affected over 31 million people all over the world till date. This virus shares around 80% of genome similarity with SARS-CoV. In this perspective, we have explored three major targets namely; SARS-CoV-2 spike (S) protein, RNA dependent RNA polymerase, and 3CL or M(pro) Protease for the inhibition of SARS-CoV-2. These targets have attracted attention of the medicinal chemists working on computer-aided drug design in developing new small molecules that might inhibit these targets for combating COVID-19 disease. Moreover, we have compared the similarity of these target proteins with earlier reported coronavirus (SARS-CoV). We have observed that both the coronaviruses share around 80% similarity in their amino acid sequence. The key amino acid interactions which can play a crucial role in designing new small molecule inhibitors against COVID-19 have been reported in this perspective. Authors believe that this study will help the medicinal chemists to understand the key amino acids essential for interactions at the active site of target proteins in SARS-CoV-2, based on their similarity with earlier reported viruses. In this review, we have also described the lead molecules under various clinical trials for their efficacy against COVID-19. |Amino Acid Sequence[MESH] |Animals[MESH] |Antiviral Agents/*metabolism/therapeutic use[MESH] |Binding Sites[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/epidemiology/virology[MESH] |Drug Repositioning[MESH] |Humans[MESH] |Protein Binding[MESH] |SARS-CoV-2/*chemistry/drug effects[MESH] |Severe acute respiratory syndrome-related coronavirus/*chemistry[MESH] |Viral Nonstructural Proteins/chemistry/*metabolism[MESH]A perspective on potential target proteins of COVID-19: Comparison wit(epmc).pdf DeepDyve Pubget Overpricing