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10.1016/j.bioorg.2020.104320 http://scihub22266oqcxt.onion/10.1016/j.bioorg.2020.104320 33142428!ä!33142428 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Chem 2020 ; 104 (ä): 104320 Nephropedia Template TP {{tp|p=33142428|t=2020. Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents |pdf=|usr=}}{{33142428}} gab.com Text Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents JO: Bioorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=33142428 #FOAvip In the present study, we intend to synthesize a series of novel substituted phenyl azetidine-2-one sulphonyl derivatives. The entire set of derivatives 5 (a-t) were screened for in-vitro antibacterial, and antifungal activity, and among them eleven compounds were further screened for the antiviral activity to predict their efficacy against pathogenic viruses. Interestingly, compound 5d, 5e, 5f, 5h, 5i, and 5j showed similar or better antibacterial activity as compared to ampicillin (standard). Moreover, compounds 5h, 5i, 5j, and 5q showed good inhibitory activity against fungal strains whereas other derivatives had mild or diminished activity in comparison with standard drug clotrimazole. The antimicrobial study indicated that compounds having electron-withdrawing groups showed the highest activity. Interestingly, these tested compounds showed weak antiviral activity against Vaccinia virus, Human Coronavirus (229E), Reovirus-1, Herpes simplex virus, Sindbis virus, Coxsackievirus B4, Yellow Fever virus, and Influenza B virus in HEL cell, Vero cell, and MDCK cell cultures. The findings of the present study might open new avenues to target human disease-causing deadly microbes and viruses. Twit Text FOAVip Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents ????Bioorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=33142428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33142428 #FOAvip English Wikipedia <ref>{{Cite pmid|33142428}}</ref> Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents #MMPMID33142428 Mandal MK; Ghosh S; Bhat HR; Naesens L; Singh UP Bioorg Chem 2020[Nov]; 104 (ä): 104320 PMID33142428show ga In the present study, we intend to synthesize a series of novel substituted phenyl azetidine-2-one sulphonyl derivatives. The entire set of derivatives 5 (a-t) were screened for in-vitro antibacterial, and antifungal activity, and among them eleven compounds were further screened for the antiviral activity to predict their efficacy against pathogenic viruses. Interestingly, compound 5d, 5e, 5f, 5h, 5i, and 5j showed similar or better antibacterial activity as compared to ampicillin (standard). Moreover, compounds 5h, 5i, 5j, and 5q showed good inhibitory activity against fungal strains whereas other derivatives had mild or diminished activity in comparison with standard drug clotrimazole. The antimicrobial study indicated that compounds having electron-withdrawing groups showed the highest activity. Interestingly, these tested compounds showed weak antiviral activity against Vaccinia virus, Human Coronavirus (229E), Reovirus-1, Herpes simplex virus, Sindbis virus, Coxsackievirus B4, Yellow Fever virus, and Influenza B virus in HEL cell, Vero cell, and MDCK cell cultures. The findings of the present study might open new avenues to target human disease-causing deadly microbes and viruses. |Animals[MESH] |Anti-Bacterial Agents/chemical synthesis/*pharmacology[MESH] |Antifungal Agents/chemical synthesis/*pharmacology[MESH] |Antiviral Agents/chemical synthesis/*pharmacology[MESH] |Aspergillus fumigatus/drug effects[MESH] |Aspergillus niger/drug effects[MESH] |Azetidines/chemical synthesis/*pharmacology[MESH] |Candida albicans/drug effects[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Dogs[MESH] |Escherichia coli/drug effects[MESH] |Humans[MESH] |Madin Darby Canine Kidney Cells[MESH] |Microbial Sensitivity Tests[MESH] |Molecular Structure[MESH] |Pseudomonas aeruginosa/drug effects[MESH] |Staphylococcus aureus/drug effects[MESH] |Structure-Activity Relationship[MESH] |Sulfonamides/chemical synthesis/*pharmacology[MESH] |Vero Cells[MESH]Synthesis and biological evaluation of substituted phenyl azetidine-2-(epmc).pdf DeepDyve Pubget Overpricing