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10.15252/embj.2020105896 http://scihub22266oqcxt.onion/10.15252/embj.2020105896 33140861!7737620!33140861     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2020 ; 39 (24): e105896 Nephropedia Template TP {{tp|p=33140861|t=2020. Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage |pdf=|usr=}}{{33140861}} gab.com Text Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=33140861 #FOAvip COVID-19 is characterized by dysregulated immune responses, metabolic dysfunction and adverse effects on the function of multiple organs. To understand host responses to COVID-19 pathophysiology, we combined transcriptomics, proteomics, and metabolomics to identify molecular markers in peripheral blood and plasma samples of 66 COVID-19-infected patients experiencing a range of disease severities and 17 healthy controls. A large number of expressed genes, proteins, metabolites, and extracellular RNAs (exRNAs) exhibit strong associations with various clinical parameters. Multiple sets of tissue-specific proteins and exRNAs varied significantly in both mild and severe patients suggesting a potential impact on tissue function. Chronic activation of neutrophils, IFN-I signaling, and a high level of inflammatory cytokines were observed in patients with severe disease progression. In contrast, COVID-19-infected patients experiencing milder disease symptoms showed robust T-cell responses. Finally, we identified genes, proteins, and exRNAs as potential biomarkers that might assist in predicting the prognosis of SARS-CoV-2 infection. These data refine our understanding of the pathophysiology and clinical progress of COVID-19. Twit Text FOAVip Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=33140861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33140861 #FOAvip English Wikipedia <ref>{{Cite pmid|33140861}}</ref> Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage #MMPMID33140861 Chen YM; Zheng Y; Yu Y; Wang Y; Huang Q; Qian F; Sun L; Song ZG; Chen Z; Feng J; An Y; Yang J; Su Z; Sun S; Dai F; Chen Q; Lu Q; Li P; Ling Y; Yang Z; Tang H; Shi L; Jin L; Holmes EC; Ding C; Zhu TY; Zhang YZ EMBO J 2020[Dec]; 39 (24): e105896 PMID33140861show ga COVID-19 is characterized by dysregulated immune responses, metabolic dysfunction and adverse effects on the function of multiple organs. To understand host responses to COVID-19 pathophysiology, we combined transcriptomics, proteomics, and metabolomics to identify molecular markers in peripheral blood and plasma samples of 66 COVID-19-infected patients experiencing a range of disease severities and 17 healthy controls. A large number of expressed genes, proteins, metabolites, and extracellular RNAs (exRNAs) exhibit strong associations with various clinical parameters. Multiple sets of tissue-specific proteins and exRNAs varied significantly in both mild and severe patients suggesting a potential impact on tissue function. Chronic activation of neutrophils, IFN-I signaling, and a high level of inflammatory cytokines were observed in patients with severe disease progression. In contrast, COVID-19-infected patients experiencing milder disease symptoms showed robust T-cell responses. Finally, we identified genes, proteins, and exRNAs as potential biomarkers that might assist in predicting the prognosis of SARS-CoV-2 infection. These data refine our understanding of the pathophysiology and clinical progress of COVID-19. |Biomarkers/blood[MESH] |COVID-19/*blood/immunology/*pathology/virology[MESH] |Female[MESH] |Genomics/methods[MESH] |Humans[MESH] |Lipoproteins/metabolism[MESH] |Male[MESH] |Metabolomics/methods[MESH] |SARS-CoV-2/physiology[MESH] |Severity of Illness Index[MESH]Blood molecular markers associated with COVID-19 immunopathology and m(epmc).pdf DeepDyve Pubget Overpricing