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10.1021/acschemneuro.0c00661 http://scihub22266oqcxt.onion/10.1021/acschemneuro.0c00661 33140636!ä!33140636 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Neurosci 2020 ; 11 (22): 3701-3703 Nephropedia Template TP {{tp|p=33140636|t=2020. Toward COVID-19 Therapeutics: A Viewpoint from the Nonprotein Amino Acid Based Synthetic Peptide Design Approach |pdf=|usr=}}{{33140636}} gab.com Text Toward COVID-19 Therapeutics: A Viewpoint from the Nonprotein Amino Acid Based Synthetic Peptide Design Approach JO: ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=33140636 #FOAvip Cell entry, the fundamental step in cross-species transmission of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is initiated by the recognition of the host cell angiotensin-converting enzyme-2 (ACE2) receptor by the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. To date, several peptides have been proposed against SARS-CoV-2 both as inhibitor agents or as detection tools that can also be attached to the surfaces of nanoparticle carriers. But owing to their natural amino acid sequences, such peptides cannot be considered as efficient therapeutic candidates from a biostability point of view. This discussion demonstrates the design strategy of synthetic nonprotein amino acid substituted peptides with enhanced biostability and binding affinity, the implication of which can make those peptides potential therapeutic agents for inhibition and simple detection tools. Twit Text FOAVip Toward COVID-19 Therapeutics: A Viewpoint from the Nonprotein Amino Acid Based Synthetic Peptide Design Approach ????ACS Chem Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=33140636 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33140636 #FOAvip English Wikipedia <ref>{{Cite pmid|33140636}}</ref> Toward COVID-19 Therapeutics: A Viewpoint from the Nonprotein Amino Acid Based Synthetic Peptide Design Approach #MMPMID33140636 Bhattacharjee S ACS Chem Neurosci 2020[Nov]; 11 (22): 3701-3703 PMID33140636show ga Cell entry, the fundamental step in cross-species transmission of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is initiated by the recognition of the host cell angiotensin-converting enzyme-2 (ACE2) receptor by the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. To date, several peptides have been proposed against SARS-CoV-2 both as inhibitor agents or as detection tools that can also be attached to the surfaces of nanoparticle carriers. But owing to their natural amino acid sequences, such peptides cannot be considered as efficient therapeutic candidates from a biostability point of view. This discussion demonstrates the design strategy of synthetic nonprotein amino acid substituted peptides with enhanced biostability and binding affinity, the implication of which can make those peptides potential therapeutic agents for inhibition and simple detection tools. |*Betacoronavirus/drug effects/genetics[MESH] |*Drug Design[MESH] |Amino Acid Sequence[MESH] |Antiviral Agents/metabolism/*therapeutic use[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/genetics/metabolism[MESH] |Humans[MESH] |Pandemics[MESH] |Peptide Fragments/genetics/metabolism/*therapeutic use[MESH] |Pneumonia, Viral/*drug therapy/genetics/metabolism[MESH] |Protein Binding/physiology[MESH] |SARS-CoV-2[MESH]Toward COVID-19 Therapeutics: A Viewpoint from the Nonprotein Amino Ac(epmc).pdf DeepDyve Pubget Overpricing