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10.1007/s10072-020-04870-z

http://scihub22266oqcxt.onion/10.1007/s10072-020-04870-z
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suck abstract from ncbi


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pmid33140308      Neurol+Sci 2021 ; 42 (1): 25-33
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  • Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients #MMPMID33140308
  • Cheruiyot I; Sehmi P; Ominde B; Bundi P; Mislani M; Ngure B; Olabu B; Ogeng'o JA
  • Neurol Sci 2021[Jan]; 42 (1): 25-33 PMID33140308show ga
  • BACKGROUND: Emerging evidence suggests that a subset of coronavirus disease 2019 (COVID-19) patients may present with or develop cerebrovascular disease during the course of hospitalization. Whereas ischemic stroke in COVID-19 patients has been well described, data on intracranial hemorrhage (ICH) in these patients is still limited. We, therefore, conducted a rapid systematic review of current scientific literature to identify and consolidate evidence of ICH in COVID-19 patients. METHODS: A systematic search of literature was conducted between November 1, 2019, and August 14, 2020, on PubMed and China National Knowledge Infrastructure (CNKI) to identify eligible studies. RESULTS: A total of 23 studies describing ICH in 148 COVID-19 patients were included. The pooled incidence of ICH in COVID-19 patients was 0.7% (95% CI 0.5-0.9), with low levels of inter-study heterogeneity observed (I(2) = 33.6%, Cochran's Q = 12.05, p = 0.149). Most of the patients were elderly male patients (65.8%) with comorbidities, the most common being systemic hypertension (54%). Hemorrhage involving multiple cranial compartments was reported in 9.5% of cases. Single compartments were involved in the rest, with intraparenchymal hemorrhage (IPH) being the most common variety (62.6%) and intraventricular hemorrhage (IVH) the least common (1.4%). Half of these patients were on some form of anticoagulation. Overall, the mortality rate in the COVID-19 patients with ICH was about 48.6%. CONCLUSION: Although relatively uncommon among COVID-19 patients, ICH is associated with a high mortality rate. Early identification of patients at risk of developing ICH, particularly with comorbid conditions and on anticoagulant therapy, may be important to improve outcomes.
  • |COVID-19/*complications/*mortality[MESH]
  • |Humans[MESH]


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