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10.1007/s00464-020-08101-6 http://scihub22266oqcxt.onion/10.1007/s00464-020-08101-6 33140152!7605488!33140152     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33140152&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Surg+Endosc 2021 ; 35 (11): 6081-6088 Nephropedia Template TP {{tp|p=33140152|t=2021. Modeling the impact of delaying surgery for early esophageal cancer in the era of COVID-19 |pdf=|usr=}}{{33140152}} gab.com Text Modeling the impact of delaying surgery for early esophageal cancer in the era of COVID-19 JO: Surg Endosc http://www.kidney.de/pget.php?&tw=1&pmid=33140152 #FOAvip BACKGROUND: Surgical society guidelines have recommended changing the treatment strategy for early esophageal cancer during the novel coronavirus (COVID-19) pandemic. Delaying resection can allow for interim disease progression, but the impact of this delay on mortality is unknown. The COVID-19 infection rate at which immediate operative risk exceeds benefit is unknown. We sought to model immediate versus delayed surgical resection in a T1b esophageal adenocarcinoma. METHODS: A decision analysis model was developed, and sensitivity analyses performed. The base case was a 65-year-old male smoker presenting with cT1b esophageal adenocarcinoma scheduled for esophagectomy during the COVID-19 pandemic. We compared immediate surgical resection to delayed resection after 3 months. The likelihood of key outcomes was derived from the literature where available. The outcome was 5-year overall survival. RESULTS: Proceeding with immediate esophagectomy for the base case scenario resulted in slightly improved 5-year overall survival when compared to delaying surgery by 3 months (5-year overall survival 0.74 for immediate and 0.73 for delayed resection). In sensitivity analyses, a delayed approach became preferred when the probability of perioperative COVID-19 infection increased above 7%. CONCLUSIONS: Immediate resection of early esophageal cancer during the COVID-19 pandemic did not decrease 5-year survival when compared to resection after 3 months for the base case scenario. However, as the risk of perioperative COVID-19 infection increases above 7%, a delayed approach has improved 5-year survival. This balance should be frequently re-examined by surgeons as infection risk changes in each hospital and community throughout the COVID-19 pandemic. Twit Text FOAVip Modeling the impact of delaying surgery for early esophageal cancer in the era of COVID-19 ????Surg Endosc http://www.kidney.de/pget.php?&tw=1&pmid=33140152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33140152 #FOAvip English Wikipedia <ref>{{Cite pmid|33140152}}</ref> Modeling the impact of delaying surgery for early esophageal cancer in the era of COVID-19 #MMPMID33140152 Shipe ME; Baechle JJ; Deppen SA; Gillaspie EA; Grogan EL Surg Endosc 2021[Nov]; 35 (11): 6081-6088 PMID33140152show ga BACKGROUND: Surgical society guidelines have recommended changing the treatment strategy for early esophageal cancer during the novel coronavirus (COVID-19) pandemic. Delaying resection can allow for interim disease progression, but the impact of this delay on mortality is unknown. The COVID-19 infection rate at which immediate operative risk exceeds benefit is unknown. We sought to model immediate versus delayed surgical resection in a T1b esophageal adenocarcinoma. METHODS: A decision analysis model was developed, and sensitivity analyses performed. The base case was a 65-year-old male smoker presenting with cT1b esophageal adenocarcinoma scheduled for esophagectomy during the COVID-19 pandemic. We compared immediate surgical resection to delayed resection after 3 months. The likelihood of key outcomes was derived from the literature where available. The outcome was 5-year overall survival. RESULTS: Proceeding with immediate esophagectomy for the base case scenario resulted in slightly improved 5-year overall survival when compared to delaying surgery by 3 months (5-year overall survival 0.74 for immediate and 0.73 for delayed resection). In sensitivity analyses, a delayed approach became preferred when the probability of perioperative COVID-19 infection increased above 7%. CONCLUSIONS: Immediate resection of early esophageal cancer during the COVID-19 pandemic did not decrease 5-year survival when compared to resection after 3 months for the base case scenario. However, as the risk of perioperative COVID-19 infection increases above 7%, a delayed approach has improved 5-year survival. This balance should be frequently re-examined by surgeons as infection risk changes in each hospital and community throughout the COVID-19 pandemic. |*COVID-19[MESH] |*Esophageal Neoplasms/pathology/surgery[MESH] |Aged[MESH] |Esophagectomy[MESH] |Humans[MESH] |Male[MESH] |Neoplasm Staging[MESH] |Pandemics[MESH] |SARS-CoV-2[MESH]Modeling the impact of delaying surgery for early esophageal cancer in(epmc).pdf DeepDyve Pubget Overpricing