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10.1038/s41467-020-19326-3 http://scihub22266oqcxt.onion/10.1038/s41467-020-19326-3 33139726!7606564!33139726     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 5508 Nephropedia Template TP {{tp|p=33139726|t=2020. Extensive 5 -surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast |pdf=|usr=}}{{33139726}} gab.com Text Extensive 5 -surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33139726 #FOAvip The ubiquitous redox coenzyme nicotinamide adenine dinucleotide (NAD) acts as a non-canonical cap structure on prokaryotic and eukaryotic ribonucleic acids. Here we find that in budding yeast, NAD-RNAs are abundant (>1400 species), short (<170 nt), and mostly correspond to mRNA 5'-ends. The modification percentage of transcripts is low (<5%). NAD incorporation occurs mainly during transcription initiation by RNA polymerase II, which uses distinct promoters with a YAAG core motif for this purpose. Most NAD-RNAs are 3'-truncated. At least three decapping enzymes, Rai1, Dxo1, and Npy1, guard against NAD-RNA at different cellular locations, targeting overlapping transcript populations. NAD-mRNAs are not translatable in vitro. Our work indicates that in budding yeast, most of the NAD incorporation into RNA seems to be disadvantageous to the cell, which has evolved a diverse surveillance machinery to prematurely terminate, decap and reject NAD-RNAs. Twit Text FOAVip Extensive 5 -surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33139726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33139726 #FOAvip English Wikipedia <ref>{{Cite pmid|33139726}}</ref> Extensive 5 -surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast #MMPMID33139726 Zhang Y; Kuster D; Schmidt T; Kirrmaier D; Nubel G; Ibberson D; Benes V; Hombauer H; Knop M; Jaschke A Nat Commun 2020[Nov]; 11 (1): 5508 PMID33139726show ga The ubiquitous redox coenzyme nicotinamide adenine dinucleotide (NAD) acts as a non-canonical cap structure on prokaryotic and eukaryotic ribonucleic acids. Here we find that in budding yeast, NAD-RNAs are abundant (>1400 species), short (<170 nt), and mostly correspond to mRNA 5'-ends. The modification percentage of transcripts is low (<5%). NAD incorporation occurs mainly during transcription initiation by RNA polymerase II, which uses distinct promoters with a YAAG core motif for this purpose. Most NAD-RNAs are 3'-truncated. At least three decapping enzymes, Rai1, Dxo1, and Npy1, guard against NAD-RNA at different cellular locations, targeting overlapping transcript populations. NAD-mRNAs are not translatable in vitro. Our work indicates that in budding yeast, most of the NAD incorporation into RNA seems to be disadvantageous to the cell, which has evolved a diverse surveillance machinery to prematurely terminate, decap and reject NAD-RNAs. |5' Untranslated Regions[MESH] |Cell Nucleus/genetics[MESH] |Endoribonucleases/*metabolism[MESH] |NAD/*metabolism[MESH] |Pyrophosphatases/metabolism[MESH] |RNA Caps/*metabolism[MESH] |RNA Stability[MESH] |RNA, Messenger/*metabolism[MESH] |RNA-Binding Proteins/metabolism[MESH] |Ribosomes/metabolism[MESH] |Saccharomyces cerevisiae Proteins/metabolism[MESH] |Saccharomyces cerevisiae/*genetics/metabolism[MESH]Extensive 5 -surveillance guards against non-canonical NAD-caps of nuc(epmc).pdf DeepDyve Pubget Overpricing