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10.1016/j.addr.2020.10.018 http://scihub22266oqcxt.onion/10.1016/j.addr.2020.10.018 33137363!7603972!33137363     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Drug+Deliv+Rev 2020 ; 160 (ä): 234-243 Nephropedia Template TP {{tp|p=33137363|t=2020. Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic |pdf=|usr=}}{{33137363}} gab.com Text Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=33137363 #FOAvip The Coronavirus disease 2019 (COVID-19) pandemic has led to a surge in need for alternative routes of administration of drugs for end of life and palliative care, particularly in community settings. Transmucosal routes include intranasal, buccal, sublingual and rectal. They are non-invasive routes for systemic drug delivery with the possibility of self-administration, or administration by family caregivers. In addition, their ability to offer rapid onset of action with reduced first-pass metabolism make them suitable for use in palliative and end-of-life care to provide fast relief of symptoms. This is particularly important in COVID-19, as patients can deteriorate rapidly. Despite the advantages, these routes of administration face challenges including a relatively small surface area for effective drug absorption, small volume of fluid for drug dissolution and the presence of a mucus barrier, thereby limiting the number of drugs that are suitable to be delivered through the transmucosal route. In this review, the merits, challenges and limitations of each of these transmucosal routes are discussed. The goals are to provide insights into using transmucosal drug delivery to bring about the best possible symptom management for patients at the end of life, and to inspire scientists to develop new delivery systems to provide effective symptom management for this group of patients. Twit Text FOAVip Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=33137363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33137363 #FOAvip English Wikipedia <ref>{{Cite pmid|33137363}}</ref> Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic #MMPMID33137363 Lam JKW; Cheung CCK; Chow MYT; Harrop E; Lapwood S; Barclay SIG; Wong ICK Adv Drug Deliv Rev 2020[]; 160 (ä): 234-243 PMID33137363show ga The Coronavirus disease 2019 (COVID-19) pandemic has led to a surge in need for alternative routes of administration of drugs for end of life and palliative care, particularly in community settings. Transmucosal routes include intranasal, buccal, sublingual and rectal. They are non-invasive routes for systemic drug delivery with the possibility of self-administration, or administration by family caregivers. In addition, their ability to offer rapid onset of action with reduced first-pass metabolism make them suitable for use in palliative and end-of-life care to provide fast relief of symptoms. This is particularly important in COVID-19, as patients can deteriorate rapidly. Despite the advantages, these routes of administration face challenges including a relatively small surface area for effective drug absorption, small volume of fluid for drug dissolution and the presence of a mucus barrier, thereby limiting the number of drugs that are suitable to be delivered through the transmucosal route. In this review, the merits, challenges and limitations of each of these transmucosal routes are discussed. The goals are to provide insights into using transmucosal drug delivery to bring about the best possible symptom management for patients at the end of life, and to inspire scientists to develop new delivery systems to provide effective symptom management for this group of patients. |*COVID-19 Drug Treatment[MESH] |Administration, Mucosal[MESH] |COVID-19/*epidemiology/metabolism[MESH] |Drug Delivery Systems/*methods[MESH] |Humans[MESH] |Palliative Care/*methods[MESH] |Pandemics[MESH]Transmucosal drug administration as an alternative route in palliative(epmc).pdf DeepDyve Pubget Overpricing