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10.1016/j.ejphar.2020.173705 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173705 33137330!7604074!33137330     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2021 ; 890 (ä): 173705 Nephropedia Template TP {{tp|p=33137330|t=2021. Functional and druggability analysis of the SARS-CoV-2 proteome |pdf=|usr=}}{{33137330}} gab.com Text Functional and druggability analysis of the SARS-CoV-2 proteome JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33137330 #FOAvip The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 46 million people have been infected and over 1.2 million fatalities. With the purpose of contributing to the development of effective therapeutics, we performed an in silico determination of binding hot-spots and an assessment of their druggability within the complete SARS-CoV-2 proteome. All structural, non-structural, and accessory proteins have been studied, and whenever experimental structural data of SARS-CoV-2 proteins were not available, homology models were built based on solved SARS-CoV structures. Several potential allosteric or protein-protein interaction druggable sites on different viral targets were identified, knowledge that could be used to expand current drug discovery endeavors beyond the currently explored cysteine proteases and the polymerase complex. It is our hope that this study will support the efforts of the scientific community both in understanding the molecular determinants of this disease and in widening the repertoire of viral targets in the quest for repurposed or novel drugs against COVID-19. Twit Text FOAVip Functional and druggability analysis of the SARS-CoV-2 proteome ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33137330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33137330 #FOAvip English Wikipedia <ref>{{Cite pmid|33137330}}</ref> Functional and druggability analysis of the SARS-CoV-2 proteome #MMPMID33137330 Cavasotto CN; Lamas MS; Maggini J Eur J Pharmacol 2021[Jan]; 890 (ä): 173705 PMID33137330show ga The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 46 million people have been infected and over 1.2 million fatalities. With the purpose of contributing to the development of effective therapeutics, we performed an in silico determination of binding hot-spots and an assessment of their druggability within the complete SARS-CoV-2 proteome. All structural, non-structural, and accessory proteins have been studied, and whenever experimental structural data of SARS-CoV-2 proteins were not available, homology models were built based on solved SARS-CoV structures. Several potential allosteric or protein-protein interaction druggable sites on different viral targets were identified, knowledge that could be used to expand current drug discovery endeavors beyond the currently explored cysteine proteases and the polymerase complex. It is our hope that this study will support the efforts of the scientific community both in understanding the molecular determinants of this disease and in widening the repertoire of viral targets in the quest for repurposed or novel drugs against COVID-19. |*Models, Molecular[MESH] |*Proteome[MESH] |Antiviral Agents/therapeutic use[MESH] |Binding Sites[MESH] |COVID-19 Drug Treatment[MESH] |Drug Discovery[MESH] |Humans[MESH] |SARS-CoV-2/*metabolism/pathogenicity[MESH]Functional and druggability analysis of the SARS-CoV-2 proteome (epmc).pdf DeepDyve Pubget Overpricing