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10.1371/journal.ppat.1009013 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009013 33137165!7605623!33137165     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2020 ; 16 (11): e1009013 Nephropedia Template TP {{tp|p=33137165|t=2020. The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors |pdf=|usr=}}{{33137165}} gab.com Text The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33137165 #FOAvip Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into humans, causing highly prevalent and severe respiratory diseases, often with fatal outcomes. CoVs are a large group of enveloped, single-stranded, positive-sense RNA viruses, which encode large replicase polyproteins that are processed by viral peptidases to generate the nonstructural proteins (Nsps) that mediate viral RNA synthesis. Papain-like peptidases (PLPs) and chymotrypsin-like cysteine 3C-like peptidase are essential for coronaviral replication and represent attractive antiviral drug targets. Furthermore, CoVs utilize the activation of their envelope spike glycoproteins by host cell peptidases to gain entry into cells. CoVs have evolved multiple strategies for spike protein activation, including the utilization of lysosomal cysteine cathepsins. In this review, viral and host peptidases involved in CoV cell entry and replication are discussed in depth, with an emphasis on papain-like cysteine cathepsins. Furthermore, important findings on cysteine peptidase inhibitors with regard to virus attenuation are highlighted as well as the potential of such inhibitors for future treatment strategies for CoV-related diseases. Twit Text FOAVip The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33137165 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33137165 #FOAvip English Wikipedia <ref>{{Cite pmid|33137165}}</ref> The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors #MMPMID33137165 Pislar A; Mitrovic A; Sabotic J; Pecar Fonovic U; Perisic Nanut M; Jakos T; Senjor E; Kos J PLoS Pathog 2020[Nov]; 16 (11): e1009013 PMID33137165show ga Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into humans, causing highly prevalent and severe respiratory diseases, often with fatal outcomes. CoVs are a large group of enveloped, single-stranded, positive-sense RNA viruses, which encode large replicase polyproteins that are processed by viral peptidases to generate the nonstructural proteins (Nsps) that mediate viral RNA synthesis. Papain-like peptidases (PLPs) and chymotrypsin-like cysteine 3C-like peptidase are essential for coronaviral replication and represent attractive antiviral drug targets. Furthermore, CoVs utilize the activation of their envelope spike glycoproteins by host cell peptidases to gain entry into cells. CoVs have evolved multiple strategies for spike protein activation, including the utilization of lysosomal cysteine cathepsins. In this review, viral and host peptidases involved in CoV cell entry and replication are discussed in depth, with an emphasis on papain-like cysteine cathepsins. Furthermore, important findings on cysteine peptidase inhibitors with regard to virus attenuation are highlighted as well as the potential of such inhibitors for future treatment strategies for CoV-related diseases. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Coronavirus Infections/drug therapy/*virology[MESH] |Coronavirus/*drug effects[MESH] |Cysteine Proteinase Inhibitors/*pharmacology[MESH] |Humans[MESH] |Virus Internalization/*drug effects[MESH]The role of cysteine peptidases in coronavirus cell entry and replicat(epmc).pdf DeepDyve Pubget Overpricing