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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Vitam+Nutr+Res 2021 ; 91 (3-4): 200-203 Nephropedia Template TP
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No significant association between vitamin D and COVID-19: A retrospective study from a northern Italian hospital #MMPMID33135597
Ferrari D; Locatelli M
Int J Vitam Nutr Res 2021[Jun]; 91 (3-4): 200-203 PMID33135597show ga
The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically, COVID-19 shows a broad range of manifestations: from asymptomatic to severe and possibly lethal interstitial pneumonia. Several studies suggested the involvement of Vitamin-D (VitD) in reducing the risk of COVID-19 infections/severity. However, most of them are based on circumstantial evidences, like the association between latitude-related sunlight exposure and mortality rate, while studies based on patients' VitD measurements are still scarce. Therefore, we retrospectively analyzed the VitD levels (measured as 25-hydroxyvitamin-D) from a cohort of 347 patients admitted to a northern Italian Hospital as suspected COVID-19s. Of them, 128 were positive (83 males, aged 62.7 +/- 14.2 and 45 females, aged 69.3 +/- 15.6) and 219 were negative (107 males, aged 62.8 +/- 19.5 and 112 females, aged 54.3 +/- 20.1). The averaged VitD levels were similar in the two groups: 21.8 +/- 16.1 ng/mL and 22.8 +/- 14.0 ng/mL for the COVID-19 positive and negative group respectively (p-value: 0.39), as well as the percentage of individuals having VitD levels below 30 ng/mL: 78.9% and 73.5% for the COVID-19 positive and negative group respectively. Because a large portion of patients were below the suggested 30 ng/mL threshold, we can't exclude that VitD supplementation, restoring normal levels, might be beneficial in reducing the risk of infection.