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10.1016/j.isci.2020.101735 http://scihub22266oqcxt.onion/10.1016/j.isci.2020.101735 33134887!7586930!33134887     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2020 ; 23 (11): 101735 Nephropedia Template TP {{tp|p=33134887|t=2020. Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human Milk |pdf=|usr=}}{{33134887}} gab.com Text Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human Milk JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33134887 #FOAvip The SARS-CoV-2 immune response in human milk has not yet been examined, although protecting infants and young children from COVID-19 is critical for limiting community transmission and preventing serious illness and death. Here, milk samples from eight COVID-19-recovered and seven COVID-19-suspected donors were tested for antibody (Ab) binding to the SARS-CoV-2 Spike protein. All samples exhibited significant specific IgA reactivity to the full Spike, whereas 80% exhibited significant IgA and secretory (s)Ab binding to the Receptor-Binding Domain (RBD). Additionally, 67% samples exhibited IgG and/or IgM binding to RBD. IgA and sAb titers were highly correlated, indicating most IgA to be sIgA. Overall, these data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals. Further research is highly warranted to determine Ab functionality and the potential for exploiting extracted milk sIgA for therapeutic use. Twit Text FOAVip Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human Milk ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33134887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33134887 #FOAvip English Wikipedia <ref>{{Cite pmid|33134887}}</ref> Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human Milk #MMPMID33134887 Fox A; Marino J; Amanat F; Krammer F; Hahn-Holbrook J; Zolla-Pazner S; Powell RL iScience 2020[Nov]; 23 (11): 101735 PMID33134887show ga The SARS-CoV-2 immune response in human milk has not yet been examined, although protecting infants and young children from COVID-19 is critical for limiting community transmission and preventing serious illness and death. Here, milk samples from eight COVID-19-recovered and seven COVID-19-suspected donors were tested for antibody (Ab) binding to the SARS-CoV-2 Spike protein. All samples exhibited significant specific IgA reactivity to the full Spike, whereas 80% exhibited significant IgA and secretory (s)Ab binding to the Receptor-Binding Domain (RBD). Additionally, 67% samples exhibited IgG and/or IgM binding to RBD. IgA and sAb titers were highly correlated, indicating most IgA to be sIgA. Overall, these data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals. Further research is highly warranted to determine Ab functionality and the potential for exploiting extracted milk sIgA for therapeutic use. äRobust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human(epmc).pdf DeepDyve Pubget Overpricing