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10.1016/j.carpath.2020.107300

http://scihub22266oqcxt.onion/10.1016/j.carpath.2020.107300
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33132119!7583586!33132119
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suck abstract from ncbi


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pmid33132119      Cardiovasc+Pathol 2021 ; 50 (ä): 107300
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  • Myocarditis is rare in COVID-19 autopsies: cardiovascular findings across 277 postmortem examinations #MMPMID33132119
  • Halushka MK; Vander Heide RS
  • Cardiovasc Pathol 2021[Jan]; 50 (ä): 107300 PMID33132119show ga
  • The COVID-19 pandemic, the result of severe acute respiratory syndrome (SARS)-CoV-2, is a major cause of worldwide mortality with a significant cardiovascular component. While a number of different cardiovascular histopathologies have been reported at postmortem examination, their incidence is unknown, due to limited numbers of cases in any given study. A literature review was performed identifying 277 autopsied hearts across 22 separate publications of COVID-19 positive patients. The median age of the autopsy cohort was 75 and 97.6% had one or more comorbidities. Initial review of the data indicate that myocarditis was present in 20 hearts (7.2%); however, closer examination of additional reported information revealed that most cases were likely not functionally significant and the true prevalence of myocarditis is likely much lower (<2%). At least one acute, potentially COVID-19-related cardiovascular histopathologic finding, such as macro or microvascular thrombi, inflammation, or intraluminal megakaryocytes, was reported in 47.8% of cases. Significant differences in reporting of histopathologic findings occurred between studies indicating strong biases in observations and the need for more consistency in reporting. In conclusion, across 277 cases, COVID-19-related cardiac histopathological findings, are common, while myocarditis is rare.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Autopsy[MESH]
  • |COVID-19/*complications/mortality/virology[MESH]
  • |Cause of Death[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myocarditis/mortality/*pathology/virology[MESH]
  • |Myocardium/*pathology[MESH]
  • |Risk Factors[MESH]


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