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10.1016/j.imbio.2020.152008 http://scihub22266oqcxt.onion/10.1016/j.imbio.2020.152008 33130519!7434692!33130519     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunobiology 2020 ; 225 (6): 152008 Nephropedia Template TP {{tp|p=33130519|t=2020. Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies |pdf=|usr=}}{{33130519}} gab.com Text Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies JO: Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=33130519 #FOAvip The current coronavirus pandemic, COVID-19, is the third outbreak of disease caused by the coronavirus family, after Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. It is an acute infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This severe disease is characterised by acute respiratory distress syndrome, septic shock, metabolic acidosis, coagulation dysfunction, and multiple organ dysfunction syndromes. Currently, no drugs or vaccines exist against the disease and the only course of treatment is symptom management involving mechanical ventilation, immune suppressants, and repurposed drugs. The severe form of the disease has a relatively high mortality rate. The last six months have seen an explosion of information related to the host receptors, virus transmission, virus structure-function relationships, pathophysiology, co-morbidities, immune response, treatment and the most promising vaccines. This review takes a critically comprehensive look at various aspects of the host-pathogen interaction in COVID-19. We examine the genomic aspects of SARS-CoV-2, modulation of innate and adaptive immunity, complement-triggered microangiopathy, and host transmission modalities. We also examine its pathophysiological impact during pregnancy, in addition to emphasizing various gaps in our knowledge. The lessons learnt from various clinical trials involving repurposed drugs have been summarised. We also highlight the rationale and likely success of the most promising vaccine candidates. Twit Text FOAVip Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies ????Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=33130519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33130519 #FOAvip English Wikipedia <ref>{{Cite pmid|33130519}}</ref> Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies #MMPMID33130519 Varghese PM; Tsolaki AG; Yasmin H; Shastri A; Ferluga J; Vatish M; Madan T; Kishore U Immunobiology 2020[Nov]; 225 (6): 152008 PMID33130519show ga The current coronavirus pandemic, COVID-19, is the third outbreak of disease caused by the coronavirus family, after Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. It is an acute infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This severe disease is characterised by acute respiratory distress syndrome, septic shock, metabolic acidosis, coagulation dysfunction, and multiple organ dysfunction syndromes. Currently, no drugs or vaccines exist against the disease and the only course of treatment is symptom management involving mechanical ventilation, immune suppressants, and repurposed drugs. The severe form of the disease has a relatively high mortality rate. The last six months have seen an explosion of information related to the host receptors, virus transmission, virus structure-function relationships, pathophysiology, co-morbidities, immune response, treatment and the most promising vaccines. This review takes a critically comprehensive look at various aspects of the host-pathogen interaction in COVID-19. We examine the genomic aspects of SARS-CoV-2, modulation of innate and adaptive immunity, complement-triggered microangiopathy, and host transmission modalities. We also examine its pathophysiological impact during pregnancy, in addition to emphasizing various gaps in our knowledge. The lessons learnt from various clinical trials involving repurposed drugs have been summarised. We also highlight the rationale and likely success of the most promising vaccine candidates. |Adaptive Immunity/*immunology[MESH] |COVID-19/*immunology/prevention & control/virology[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Immunity, Innate/*immunology[MESH] |SARS-CoV-2/genetics/*immunology/pathogenicity[MESH] |Vaccination[MESH] |Viral Vaccines/administration & dosage/immunology[MESH] |Virulence/genetics/immunology[MESH]Host-pathogen interaction in COVID-19: Pathogenesis, potential therape(epmc).pdf DeepDyve Pubget Overpricing