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10.1016/j.ejphar.2020.173694

http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173694
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33130275!7604012!33130275
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suck abstract from ncbi

pmid33130275      Eur+J+Pharmacol 2021 ; 891 (?): 173694
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  • COVID-19 and antimalarials Have we been doing it wrong all along? #MMPMID33130275
  • Cismaru CA; Cismaru GL; Seyed Nabavi F; Seyed Nabavi M; Berindan-Neagoe I
  • Eur J Pharmacol 2021[Jan]; 891 (?): 173694 PMID33130275show ga
  • In the context of the current SARS-CoV-2 pandemic, associations of drugs which interfere with specific steps of the viral infectious cycle are currently being exploited as therapeutic strategies since a specific treatment by vaccination is still unavailable. A widespread association of repurposed agents is the combination of the antimalarial drug Hydroxychloroquine and the macrolide antibiotic Azithromycin in the setting of clinical trials. But a closer analysis of their mechanism of action suggests that their concomitant administration may be impractical, and this is supported by experimental data with other agents of the same classes. However a sequential administration of the lysosomotropic antimalarial with the addition of the macrolide proton pump inhibitor after the first has reached a certain threshold could better exploit their antiviral potential.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/virology[MESH]
  • |*Drug Repositioning/methods/trends[MESH]
  • |*SARS-CoV-2/drug effects/physiology[MESH]
  • |Anti-Bacterial Agents/pharmacology[MESH]
  • |Antimalarials/pharmacology[MESH]
  • |Azithromycin/*pharmacology[MESH]
  • |Drug Interactions/physiology[MESH]
  • |Humans[MESH]


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