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10.1016/j.media.2020.101836

http://scihub22266oqcxt.onion/10.1016/j.media.2020.101836
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33129141!7543739!33129141
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suck abstract from ncbi


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pmid33129141      Med+Image+Anal 2021 ; 67 (ä): 101836
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  • Dual-branch combination network (DCN): Towards accurate diagnosis and lesion segmentation of COVID-19 using CT images #MMPMID33129141
  • Gao K; Su J; Jiang Z; Zeng LL; Feng Z; Shen H; Rong P; Xu X; Qin J; Yang Y; Wang W; Hu D
  • Med Image Anal 2021[Jan]; 67 (ä): 101836 PMID33129141show ga
  • The recent global outbreak and spread of coronavirus disease (COVID-19) makes it an imperative to develop accurate and efficient diagnostic tools for the disease as medical resources are getting increasingly constrained. Artificial intelligence (AI)-aided tools have exhibited desirable potential; for example, chest computed tomography (CT) has been demonstrated to play a major role in the diagnosis and evaluation of COVID-19. However, developing a CT-based AI diagnostic system for the disease detection has faced considerable challenges, which is mainly due to the lack of adequate manually-delineated samples for training, as well as the requirement of sufficient sensitivity to subtle lesions in the early infection stages. In this study, we developed a dual-branch combination network (DCN) for COVID-19 diagnosis that can simultaneously achieve individual-level classification and lesion segmentation. To focus the classification branch more intensively on the lesion areas, a novel lesion attention module was developed to integrate the intermediate segmentation results. Furthermore, to manage the potential influence of different imaging parameters from individual facilities, a slice probability mapping method was proposed to learn the transformation from slice-level to individual-level classification. We conducted experiments on a large dataset of 1202 subjects from ten institutes in China. The results demonstrated that 1) the proposed DCN attained a classification accuracy of 96.74% on the internal dataset and 92.87% on the external validation dataset, thereby outperforming other models; 2) DCN obtained comparable performance with fewer samples and exhibited higher sensitivity, especially in subtle lesion detection; and 3) DCN provided good interpretability on the loci of infection compared to other deep models due to its classification guided by high-level semantic information. An online CT-based diagnostic platform for COVID-19 derived from our proposed framework is now available.
  • |*Neural Networks, Computer[MESH]
  • |*Tomography, X-Ray Computed[MESH]
  • |COVID-19/classification/*diagnostic imaging[MESH]
  • |Humans[MESH]
  • |Pneumonia, Viral/classification/*diagnostic imaging[MESH]
  • |Radiography, Thoracic[MESH]
  • |SARS-CoV-2[MESH]


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