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10.1111/tbed.13907

http://scihub22266oqcxt.onion/10.1111/tbed.13907
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33128861!8085186!33128861
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suck abstract from ncbi


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pmid33128861      Transbound+Emerg+Dis 2021 ; 68 (4): 1868-1885
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  • Animal models for SARS-CoV-2 research: A comprehensive literature review #MMPMID33128861
  • Pandey K; Acharya A; Mohan M; Ng CL; Reid SP; Byrareddy SN
  • Transbound Emerg Dis 2021[Jul]; 68 (4): 1868-1885 PMID33128861show ga
  • Emerging and re-emerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has caused a global public health emergency. To date, the molecular mechanism of transmission of SARS-CoV-2, its clinical manifestations and pathogenesis is not completely understood. The global scientific community has intensified its efforts in understanding the biology of SARS-CoV-2 for development of vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID-19. To understand the pathophysiology of SARS-CoV-2, appropriate animal models that mimic the biology of human SARS-CoV-2 infection are urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). Importantly, we discuss models that are appropriate for SARS-CoV-2 as well as the advantages and disadvantages of various available methods.
  • |*COVID-19/veterinary[MESH]
  • |*Severe acute respiratory syndrome-related coronavirus[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |Middle East Respiratory Syndrome Coronavirus[MESH]
  • |Models, Animal[MESH]
  • |Pandemics[MESH]


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