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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cytometry+A 2020 ; 97 (12): 1217-1221 Nephropedia Template TP
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Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review #MMPMID33125816
Benlyamani I; Venet F; Coudereau R; Gossez M; Monneret G
Cytometry A 2020[Dec]; 97 (12): 1217-1221 PMID33125816show ga
Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. (c) 2020 International Society for Advancement of Cytometry.