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10.1021/acssensors.0c01377

http://scihub22266oqcxt.onion/10.1021/acssensors.0c01377
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33124797!ä!33124797

suck abstract from ncbi


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pmid33124797      ACS+Sens 2020 ; 5 (11): 3328-3345
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  • Roadmap to the Bioanalytical Testing of COVID-19: From Sample Collection to Disease Surveillance #MMPMID33124797
  • Hosseini A; Pandey R; Osman E; Victorious A; Li F; Didar T; Soleymani L
  • ACS Sens 2020[Nov]; 5 (11): 3328-3345 PMID33124797show ga
  • The disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), has led to a global pandemic with tremendous mortality, morbidity, and economic loss. The current lack of effective vaccines and treatments places tremendous value on widespread screening, early detection, and contact tracing of COVID-19 for controlling its spread and minimizing the resultant health and societal impact. Bioanalytical diagnostic technologies have played a critical role in the mitigation of the COVID-19 pandemic and will continue to be foundational in the prevention of the subsequent waves of this pandemic along with future infectious disease outbreaks. In this Review, we aim at presenting a roadmap to the bioanalytical testing of COVID-19, with a focus on the performance metrics as well as the limitations of various techniques. The state-of-the-art technologies, mostly limited to centralized laboratories, set the clinical metrics against which the emerging technologies are measured. Technologies for point-of-care and do-it-yourself testing are rapidly emerging, which open the route for testing in the community, at home, and at points-of-entry to widely screen and monitor individuals for enabling normal life despite of an infectious disease pandemic. The combination of different classes of diagnostic technologies (centralized and point-of-care and relying on multiple biomarkers) are needed for effective diagnosis, treatment selection, prognosis, patient monitoring, and epidemiological surveillance in the event of major pandemics such as COVID-19.
  • |COVID-19 Serological Testing[MESH]
  • |COVID-19 Testing/*methods[MESH]
  • |COVID-19/*diagnosis/virology[MESH]
  • |Clustered Regularly Interspaced Short Palindromic Repeats/genetics[MESH]
  • |Humans[MESH]
  • |Limit of Detection[MESH]
  • |Point-of-Care Systems[MESH]
  • |RNA, Viral/chemistry/genetics/metabolism[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2/genetics/isolation & purification[MESH]
  • |Sequence Analysis, RNA[MESH]


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