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10.4269/ajtmh.20-1110 http://scihub22266oqcxt.onion/10.4269/ajtmh.20-1110 33124544!7695090!33124544     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Trop+Med+Hyg 2020 ; 103 (6): 2412-2418 Nephropedia Template TP {{tp|p=33124544|t=2020. Factors of Severity in Patients with COVID-19: Cytokine/Chemokine Concentrations, Viral Load, and Antibody Responses |pdf=|usr=}}{{33124544}} gab.com Text Factors of Severity in Patients with COVID-19: Cytokine/Chemokine Concentrations, Viral Load, and Antibody Responses JO: Am J Trop Med Hyg http://www.kidney.de/pget.php?&tw=1&pmid=33124544 #FOAvip The severity of COVID-19 ranges from mild to critical diseases. However, limited data have been published on the detailed kinetics of viral load and host immune response throughout the disease course depending on disease severity. In this study, we comprehensively analyzed viral load, antibody responses to SARS-CoV-2, and cytokines/chemokines during the disease course, and identified the factors related to severity. Nasopharyngeal (NP) and plasma specimens were obtained from 31 patients with COVID-19 during hospitalization. Viral RNA in NP specimens was quantified by reverse transcription-PCR. Anti-SARS-CoV-2 antibodies and cytokines/chemokines in plasma specimens were analyzed by ELISA and cytometric bead array. The viral load in patients with COVID-19 peaked at the early stage of the disease and continuously decreased. Severe and critical cases showed higher viral load and prolonged viral shedding than asymptomatic and mild cases. Whereas plasma IgG was gradually increased and maintained during hospitalization, plasma IgM peaked at 3 weeks after symptom onset and dissipated. The antibody response in severe and critical cases was slightly delayed but stronger than those in others. High levels of interferon (IFN)-alpha, IFN-gamma-induced protein-10, monokine induced by IFN-gamma, and interleukin-6 at 5-10 days from symptom onset were associated with the severity of COVID-19. Our data indicate that high viral load in the respiratory tract and excessive production of cytokines and chemokines between 1 and 2 weeks from the symptom onset were significantly associated with the severity of COVID-19. Twit Text FOAVip Factors of Severity in Patients with COVID-19: Cytokine/Chemokine Concentrations, Viral Load, and Antibody Responses ????Am J Trop Med Hyg http://www.kidney.de/pget.php?&tw=1&pmid=33124544 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33124544 #FOAvip English Wikipedia <ref>{{Cite pmid|33124544}}</ref> Factors of Severity in Patients with COVID-19: Cytokine/Chemokine Concentrations, Viral Load, and Antibody Responses #MMPMID33124544 Kwon JS; Kim JY; Kim MC; Park SY; Kim BN; Bae S; Cha HH; Jung J; Kim MJ; Lee MJ; Choi SH; Chung JW; Shin EC; Kim SH Am J Trop Med Hyg 2020[Dec]; 103 (6): 2412-2418 PMID33124544show ga The severity of COVID-19 ranges from mild to critical diseases. However, limited data have been published on the detailed kinetics of viral load and host immune response throughout the disease course depending on disease severity. In this study, we comprehensively analyzed viral load, antibody responses to SARS-CoV-2, and cytokines/chemokines during the disease course, and identified the factors related to severity. Nasopharyngeal (NP) and plasma specimens were obtained from 31 patients with COVID-19 during hospitalization. Viral RNA in NP specimens was quantified by reverse transcription-PCR. Anti-SARS-CoV-2 antibodies and cytokines/chemokines in plasma specimens were analyzed by ELISA and cytometric bead array. The viral load in patients with COVID-19 peaked at the early stage of the disease and continuously decreased. Severe and critical cases showed higher viral load and prolonged viral shedding than asymptomatic and mild cases. Whereas plasma IgG was gradually increased and maintained during hospitalization, plasma IgM peaked at 3 weeks after symptom onset and dissipated. The antibody response in severe and critical cases was slightly delayed but stronger than those in others. High levels of interferon (IFN)-alpha, IFN-gamma-induced protein-10, monokine induced by IFN-gamma, and interleukin-6 at 5-10 days from symptom onset were associated with the severity of COVID-19. Our data indicate that high viral load in the respiratory tract and excessive production of cytokines and chemokines between 1 and 2 weeks from the symptom onset were significantly associated with the severity of COVID-19. |*Pandemics[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/*blood[MESH] |Asymptomatic Diseases[MESH] |Biomarkers/blood[MESH] |COVID-19 Testing/methods[MESH] |COVID-19/diagnosis/*epidemiology/*immunology/pathology[MESH] |Chemokine CXCL10/blood[MESH] |Chemokine CXCL9/blood[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/*blood[MESH] |Immunoglobulin M/*blood[MESH] |Interferon-alpha/blood[MESH] |Interleukin-6/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |RNA, Viral/*blood[MESH] |Republic of Korea/epidemiology[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH] |Severity of Illness Index[MESH]Factors of Severity in Patients with COVID-19: Cytokine/Chemokine Conc(epmc).pdf DeepDyve Pubget Overpricing