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10.1111/febs.15613 http://scihub22266oqcxt.onion/10.1111/febs.15613 33124149!8518758!33124149     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2021 ; 288 (17): 5055-5070 Nephropedia Template TP {{tp|p=33124149|t=2021. The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection |pdf=|usr=}}{{33124149}} gab.com Text The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33124149 #FOAvip The ongoing coronavirus disease 2019 (COVID-19) crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a large-scale pandemic that is afflicting millions of individuals in over 200 countries. The clinical spectrum caused by SARS-CoV-2 infections can range from asymptomatic infection to mild undifferentiated febrile illness to severe respiratory disease with multiple complications. Elderly patients (aged 60 and above) with comorbidities such as cardiovascular diseases and diabetes mellitus appear to be at highest risk of a severe disease outcome. To protect against pulmonary immunopathology caused by SARS-CoV-2 infection, the host primarily depends on two distinct defense strategies: resistance and disease tolerance. Resistance is the ability of the host to suppress and eliminate incoming viruses. By contrast, disease tolerance refers to host responses that promote host health regardless of their impact on viral replication. Disruption of either resistance or disease tolerance mechanisms or both could underpin predisposition to elevated risk of severe disease during viral infection. Aging can disrupt host resistance and disease tolerance by compromising immune functions, weakening of the unfolded protein response, progressive mitochondrial dysfunction, and altering metabolic processes. A comprehensive understanding of the molecular mechanisms underlying declining host defense in elderly individuals could thus pave the way to provide new opportunities and approaches for the treatment of severe COVID-19. Twit Text FOAVip The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33124149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33124149 #FOAvip English Wikipedia <ref>{{Cite pmid|33124149}}</ref> The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection #MMPMID33124149 Mok DZL; Chan CYY; Ooi EE; Chan KR FEBS J 2021[Sep]; 288 (17): 5055-5070 PMID33124149show ga The ongoing coronavirus disease 2019 (COVID-19) crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a large-scale pandemic that is afflicting millions of individuals in over 200 countries. The clinical spectrum caused by SARS-CoV-2 infections can range from asymptomatic infection to mild undifferentiated febrile illness to severe respiratory disease with multiple complications. Elderly patients (aged 60 and above) with comorbidities such as cardiovascular diseases and diabetes mellitus appear to be at highest risk of a severe disease outcome. To protect against pulmonary immunopathology caused by SARS-CoV-2 infection, the host primarily depends on two distinct defense strategies: resistance and disease tolerance. Resistance is the ability of the host to suppress and eliminate incoming viruses. By contrast, disease tolerance refers to host responses that promote host health regardless of their impact on viral replication. Disruption of either resistance or disease tolerance mechanisms or both could underpin predisposition to elevated risk of severe disease during viral infection. Aging can disrupt host resistance and disease tolerance by compromising immune functions, weakening of the unfolded protein response, progressive mitochondrial dysfunction, and altering metabolic processes. A comprehensive understanding of the molecular mechanisms underlying declining host defense in elderly individuals could thus pave the way to provide new opportunities and approaches for the treatment of severe COVID-19. |Aged[MESH] |Aging/*genetics[MESH] |COVID-19/*genetics/pathology/virology[MESH] |Disease Resistance/*genetics[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Immune Tolerance/genetics[MESH] |Pandemics[MESH] |SARS-CoV-2/genetics/*pathogenicity[MESH]The effects of aging on host resistance and disease tolerance to SARS-(epmc).pdf DeepDyve Pubget Overpricing