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10.3389/fcimb.2020.580096 http://scihub22266oqcxt.onion/10.3389/fcimb.2020.580096 33123500!7573563!33123500     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Infect+Microbiol 2020 ; 10 (ä): 580096 Nephropedia Template TP {{tp|p=33123500|t=2020. Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection |pdf=|usr=}}{{33123500}} gab.com Text Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33123500 #FOAvip Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1-4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased risk of severe disease occurs during secondary infection with a virus serotype distinct from that of prior dengue infection. This occurs by antibody dependent enhancement (ADE) of infection, wherein sub-neutralizing antibodies against the virus particles opsonize dengue virus entry via formation of immune complexes that interact with fragment crystallizable gamma receptors (FcgammaR) on monocytes, dendritic cells, and macrophages. The ADE phenomenon has two components: Extrinsic and Intrinsic ADE. While extrinsic ADE contributes to enhanced virus entry, intrinsic ADE results in heightened virus production by inhibition of type1 interferon and activation of interleukin-10 biosynthesis, thereby favoring a Th2 type immune response. Intrinsic ADE has greater contribution in enhancing Dengue replication as compared to extrinsic ADE. Detailed elucidation of intrinsic ADE during secondary dengue infection can increase our understanding of DENV-pathogenesis and aid in the development of host-targeting antivirals. Here we review literature focusing on intrinsic factors contributing to severe dengue pathology and suggest possible avenues for further research. Twit Text FOAVip Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33123500 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33123500 #FOAvip English Wikipedia <ref>{{Cite pmid|33123500}}</ref> Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection #MMPMID33123500 Narayan R; Tripathi S Front Cell Infect Microbiol 2020[]; 10 (ä): 580096 PMID33123500show ga Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1-4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased risk of severe disease occurs during secondary infection with a virus serotype distinct from that of prior dengue infection. This occurs by antibody dependent enhancement (ADE) of infection, wherein sub-neutralizing antibodies against the virus particles opsonize dengue virus entry via formation of immune complexes that interact with fragment crystallizable gamma receptors (FcgammaR) on monocytes, dendritic cells, and macrophages. The ADE phenomenon has two components: Extrinsic and Intrinsic ADE. While extrinsic ADE contributes to enhanced virus entry, intrinsic ADE results in heightened virus production by inhibition of type1 interferon and activation of interleukin-10 biosynthesis, thereby favoring a Th2 type immune response. Intrinsic ADE has greater contribution in enhancing Dengue replication as compared to extrinsic ADE. Detailed elucidation of intrinsic ADE during secondary dengue infection can increase our understanding of DENV-pathogenesis and aid in the development of host-targeting antivirals. Here we review literature focusing on intrinsic factors contributing to severe dengue pathology and suggest possible avenues for further research. |*Dengue[MESH] |*Dengue Virus[MESH] |Animals[MESH] |Antibodies, Viral[MESH] |Antibody-Dependent Enhancement[MESH]Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During (epmc).pdf DeepDyve Pubget Overpricing