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10.1155/2020/9421340

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33122970!7585660!33122970
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suck abstract from ncbi


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pmid33122970      Mediators+Inflamm 2020 ; 2020 (ä): 9421340
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  • Luteolin Attenuates IL-1beta-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-kappaB and MAPK Pathways #MMPMID33122970
  • Huang WC; Liou CJ; Shen SC; Hu S; Hsiao CY; Wu SJ
  • Mediators Inflamm 2020[]; 2020 (ä): 9421340 PMID33122970show ga
  • Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through anti-inflammatory activity in RPE cells. The flavonoid polyphenol luteolin (LU) has anti-inflammatory and antidiabetes activities, but its effects regarding retinal protection remain unknown. Here, we examined the ability of luteolin to alleviate markers of inflammation related to RD in cytokine-primed APPE-19 cells. We found that luteolin decreased the levels of interleukin- (IL-) 6, IL-8, soluble intercellular adhesion molecule-1 (sICAM-1), and monocyte chemoattractant protein-1 (MCP-1) and attenuated adherence of the human monocytic leukemia cell line THP-1 to IL-1beta-stimulated ARPE-19 cells. Luteolin also increased anti-inflammatory protein heme oxygenase-1 (HO-1) levels. Interestingly, luteolin induced protein kinase B (AKT) phosphorylation, thus inhibiting nuclear factor- (NF-) kappaB transfer from cytoplasm into the nucleus and suppressing mitogen-activated protein kinase (MAPK) inflammatory pathways. Furthermore, cotreatment with MAPK inhibitors and luteolin decreased inflammatory cytokine and chemokine levels, and further suppressed THP-1 adhesion. Overall, these results provide evidence that luteolin protects ARPE-19 cells from IL-1beta-stimulated increases of IL-6, IL-8, sICAM-1, and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways, thus ameliorating the inflammatory response.
  • |Cell Line[MESH]
  • |Cell Survival/drug effects[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Fluorescent Antibody Technique[MESH]
  • |Heme Oxygenase-1/metabolism[MESH]
  • |Humans[MESH]
  • |Interleukin-1beta/*pharmacology[MESH]
  • |Luteolin/*pharmacology[MESH]
  • |Mitogen-Activated Protein Kinases/*metabolism[MESH]
  • |NF-kappa B/*metabolism[MESH]
  • |Phosphorylation/drug effects[MESH]
  • |Proto-Oncogene Proteins c-akt/metabolism[MESH]


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